Myocardial infarction: stem cell transplantation for cardiac regeneration

被引：35
作者：
Carvalho, Edmund [1 ]
Verma, Paul [2 ,3 ]
Hourigan, Kerry [4 ,5 ]
Banerjee, Rinti [6 ]
机构：
[1] Indian Inst Technol, Monash Res Acad, Mumbai 400076, Maharashtra, India
[2] SARDI, Turretfield Res Ctr, Adelaide, SA, Australia
[3] Monash Univ, Stem Cells & Reprogramming Grp, Clayton, Vic 3800, Australia
[4] Monash Univ, FLAIR Lab Biomed Engn, Clayton, Vic 3800, Australia
[5] Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia
[6] Indian Inst Technol, Dept Biosci & Bioengn, Bombay, Maharashtra, India
来源：
REGENERATIVE MEDICINE | 2015年 / 10卷 / 08期
关键词：
cardiac regeneration; bench to clinic; myocardial infarction; LEFT-VENTRICULAR FUNCTION; AUTOLOGOUS SKELETAL MYOBLASTS; BONE-MARROW-CELLS; CARDIOSPHERE-DERIVED CELLS; TISSUE ENGINEERING APPLICATIONS; RANDOMIZED PHASE-1 TRIAL; ISCHEMIC CARDIOMYOPATHY; INDUCED PLURIPOTENT; PROGENITOR CELLS; HEART-FAILURE;
D O I：
10.2217/rme.15.63
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
It is estimated that by 2030, almost 23.6 million people will perish from cardiovascular disease, according to the WHO. The review discusses advances in stem cell therapy for myocardial infarction, including cell sources, methods of differentiation, expansion selection and their route of delivery. Skeletal muscle cells, hematopoietic cells and mesenchymal stem cells and embryonic stem cells-derived cardiomyocytes have advanced to the clinical stage, while induced pluripotent cells are yet to be considered clinically. Delivery of cells to the sites of injury and their subsequent retention is a major issue. The development of supportive scaffold matrices to facilitate stem cell retention and differentiation are analyzed. The review outlines clinical translation of conjugate stem cell-based cellular therapeutics post-myocardial infarction.
引用
收藏
页码：1025 / 1043
页数：19
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