Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering: in vivo behavior assessment

被引：19

作者：

Ivanoska-Dacikj, Aleksandra ^{[1
]}

Bogoeva-Gaceva, Gordana ^{[1
,2
]}

Krumme, Andres ^{[3
]}

Tarasova, Elvira ^{[3
]}

Scalera, Chiara ^{[4
]}

Stojkovski, Velimir ^{[5
]}

Gjorgoski, Icko ^{[6
]}

Ristoski, Trpe ^{[5
]}

机构：

[1] Acad Sci & Arts Republ North Macedonia, Res Ctr Environm & Mat, Krste Misirkov 2, Skopje 1000, North Macedonia

[2] Ss Cyril & Methodius Univ, Fac Technol & Met, Skopje, North Macedonia

[3] Tallinn Univ Technol, Dept Polymer Mat, Tallinn, Estonia

[4] Ab Med, Milan, Italy

[5] Ss Cyril & Methodius Univ, Fac Vet Med, Skopje, North Macedonia

[6] Ss Cyril & Methodius Univ, Fac Nat Sci & Math, Skopje, North Macedonia

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 17期

关键词：

Biodegradable scaffolds; biocompatibility; biodegradable polyurethane; electrospinning; GRAPHENE OXIDE; CYTOTOXICITY; BIOMATERIALS; DEGRADATION; FABRICATION; DELIVERY; DEVICES;

D O I：

10.1080/00914037.2019.1655754

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this work, 3D porous electrospun scaffolds based on DegraPol (R) (DP), a polyester urethane, with different concentrations of graphene oxide (GO) (0.0-2.0 wt%) were obtained. In order to produce scaffolds with increased porosity, solutions of DP and GO were co-electrospun with polyethylene oxide (PEO), which was subsequently removed. The electrospinning resulted in the formation of porous and fibrous scaffolds with superior elasticity. The colloidal Ag was successfully used as a novel method of scaffold sterilization. The results of the in vivo analysis showed scaffold degradation, absence of an inflammatory process and penetration of tissue cells in the scaffold.

引用

页码：1101 / 1111

页数：11

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