Electrocardiographic characteristics in angiographically documented occlusion of the dominant left circumflex artery with acute inferior myocardial infarction: limitations of ST elevation III/II ratio and ST deviation in lateral limb leads

Background: The prognosis of dominant left circumflex artery (LCx) occlusion-related inferior acute myocardial infarction (AMI) patients is poor, but the electrocardiographic (ECG) characteristics of this AMI entity have not been described. Methods: One hundred thirty-five patients with first dominant right coronary artery (CA) or dominant LCx-related inferior AMI were included. The characteristics of ECG obtained on admission for 55 patients with culprit lesions proximal to the first major right ventricular (RV) branch of dominant RCA (group proximal dominant RCA), 62 patients with culprit lesions distal to the first major RV branch of dominant RCA (group distal dominant RCA), and 18 patients with culprit lesions in dominant LCx (group dominant LCx) were compared. Results: There were no significant differences among the 3 groups in the prevalence regarding an S/R ratio greater than 1:3 in aVL, ST elevation in aVR (ST up arrow(aVR)), ST depression in aVR (ST down arrow(aVR)) Of 1 mm or more, and atrioventricular block. Greater ST elevation in lead III than in 11 and greater ST depression in aVL than I showed specificity of 17% and 44% to identify dominant RCA as culprit lesion, respectively. All 3 groups could be distinguished on the basis of ST up arrow(V4R), ST down arrow(V4R), ST down arrow(V3)/ST up arrow(III) of 1.2 or less, and ST down arrow(V3)/ST up arrow(III) of more than 1.2. Conclusions: Greater ST elevation in lead III than in II, greater ST depression in aVL than I, and an S/R ratio of greater than 1:3 in aVL were not useful to discriminate between dominant RCA and dominant LCx occlusion-related inferior AMI. ST-segment deviation in lead V4R and the ratio of ST down arrow(V3)/ST up arrow(III) were useful in predicting the dominant artery occlusion-related inferior AMI. (C) 2009 Elsevier Inc. All rights reserved.