Fasting and fasting-mimicking diets for chemotherapy augmentation

被引:27
作者
Brandhorst, Sebastian [1 ,2 ]
机构
[1] Univ Southern Calif, Sch Gerontol, Longev Inst, Los Angeles, CA 90089 USA
[2] Univ Southern Calif, Dept Biol Sci, Los Angeles, CA 90089 USA
关键词
Cancer; Chemotherapy; Fasting; Fasting-mimicking diet; MAMMARY-TUMOR INCIDENCE; DISEASE RISK MARKERS; GROWTH-FACTOR-I; CALORIC RESTRICTION; LIFE-SPAN; CANCER-CELLS; STRESS RESISTANCE; SPONTANEOUS TUMORIGENESIS; MOLECULAR-MECHANISMS; PROTEIN RESTRICTION;
D O I
10.1007/s11357-020-00317-7
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The increasingly older population in most developed countries will likely experience aging-related chronic diseases such as diabetes, metabolic syndrome, heart and lung diseases, osteoporosis, arthritis, dementia, and/or cancer. Genetic and environmental factors, but also lifestyle choices including physical activity and dietary habits, play essential roles in disease onset and progression. Sixty-five percent of Americans diagnosed with cancer now survive more than 5 years, making the need for informed lifestyle choices particularly important to successfully complete their treatment, increase the recovery from the cytotoxic therapy options, and improve cancer-free survival. This review will discuss the findings on the use of prolonged fasting, as well as fasting-mimicking diets to augment cancer treatment. Preclinical studies in rodents strongly support the implementation of these dietary interventions and a small number of clinical trials begin to provide encouraging results for cancer patients and cancer survivors.
引用
收藏
页码:1201 / 1216
页数:16
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