Leptospira exposure in the human environment in France: A survey in feral rodents and in fresh water

被引：57

作者：

Aviat, F. ^{[1
]}

Blanchard, B. ^{[2
]}

Michel, V. ^{[1
]}

Blanchet, B. ^{[1
]}

Branger, C. ^{[1
]}

Hars, J. ^{[3
]}

Mansotte, F. ^{[4
]}

Brasme, L. ^{[5
]}

De Champs, C. ^{[5
]}

Bolut, P. ^{[6
]}

Mondot, P. ^{[7
]}

Faliu, J. ^{[8
]}

Rochereau, S. ^{[1
]}

Kodjo, A. ^{[9
]}

Andre-Fontaine, G. ^{[1
]}

机构：

[1] Ecole Natl Vet, Unite Bacteriol Med & Mol Leptospires, F-44307 Nantes 3, France

[2] Adiagene, F-22000 St Brieuc, France

[3] Unite Sanit Faune Sauvage, ONCFS, F-38610 Gieres, France

[4] Serv Sante Environm, DDASS 44, F-44200 Nantes, France

[5] Univ Reims, Hop Robert Debre, Ctr Hosp, Lab Bacteriol Virol Hyg Hosp, F-51092 Reims, France

[6] Serv Incendie & Secours, F-85017 La Roche Sur Yon, France

[7] Serv Incendie & Secours, F-44243 La Chapelle Sur Erdre, France

[8] DRASS Champagne Ardenne, F-51037 Chalons Sur Marne, France

[9] ENVL, CNRS, UMR 5557, Ecole Natl Vet Lyon, F-69280 Marcy Letoile, France

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2009年 / 32卷 / 06期

关键词：

Leptospirosis; Microagglutination test; PCR; Rodents; Water; Hap1; LipL32; POLYMERASE-CHAIN-REACTION; PATHOGENIC LEPTOSPIRES; RATTUS-NORVEGICUS; RATS; EPIDEMIOLOGY; PREVALENCE; CITY;

D O I：

10.1016/j.cimid.2008.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper confirms the important role of rodents to be maintenance hosts of leptospires. Their role is related to renal carriage and shedding of leptospires into urine, thus contaminating fresh water. Serological and carriage of feral rodents trapped in France were determined by MAT and hap1PCR specific for pathogenic leptospires. In same areas, fresh water samples were analyzed by hap1PCR. The overall seroprevalence was 44% in 649 rodents and was similar regardless of the species. Seroprevalence for leptospirosis is about 20-53% according to species. hap1PCR (516 kidneys) showed that renal carriage was higher in brown rats (34.7%) and muskrats (15.8%) than in coypus (3.3%). hap1PCR demonstrates a significative difference (P-value > 10(-12)) for the renal carriage between the different species: muskrats and rats are more efficient maintenance hosts than coypu but all infect water. Moreover 5/38 water samples associated with human cases were hap1PCR positive and 1/113 in controlled waters. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：463 / 476

页数：14

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