Efflux pumps: an answer to Gram-negative bacterial resistance?

被引:8
|
作者
Wiggins, P [1 ]
机构
[1] PharmSouth, Dothan, AL 36303 USA
关键词
ArcA system; ArcAB system; bacterial cell walls; Escherichia coli; efflux pumps; Gram-negative organisms; Gram-positive organisms; mar operon; multi-drug resistance; protomer; residues; resistant nodulating division; TolC protein; transporter inhibitor complexes; X-ray crystallography;
D O I
10.1517/13543784.13.8.899
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:899 / 902
页数:4
相关论文
共 50 条
  • [21] Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit
    Shorr, Andrew F.
    CRITICAL CARE MEDICINE, 2009, 37 (04) : 1463 - 1469
  • [22] Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier
    Zgurskaya, Helen, I
    Rybenkov, Valentin V.
    Krishnamoorthy, Ganesh
    Leus, Inga, V
    RESEARCH IN MICROBIOLOGY, 2018, 169 (7-8) : 351 - 356
  • [23] Antimicrobial Resistance in Hospital-Acquired Gram-Negative Bacterial Infections
    Mehrad, Borna
    Clark, Nina M.
    Zhanel, George G.
    Lynch, Joseph P., III
    CHEST, 2015, 147 (05) : 1413 - 1421
  • [24] Multidrug resistance in hydrocarbon-tolerant Gram-positive and Gram-negative bacteria
    Stancu, Mihaela Marilena
    Grifoll, Magdalena
    JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2011, 57 (01) : 1 - 18
  • [25] Global travel and Gram-negative bacterial resistance; implications on clinical management
    Theriault, Nicolette
    Tillotson, Glenn
    Sandrock, Christian E.
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2021, 19 (02) : 181 - 196
  • [26] Efflux in Gram-negative bacteria: what are the latest opportunities for drug discovery?
    Gil-Gil, Teresa
    Laborda, Pablo
    Ochoa-Sanchez, Luz Edith
    Martinez, Jose Luis
    Hernando-Amado, Sara
    EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (06) : 671 - 686
  • [27] Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria
    Masi, Muriel
    Refregiers, Matthieu
    Pos, Klaas M.
    Pages, Jean-Marie
    NATURE MICROBIOLOGY, 2017, 2 (03):
  • [28] New Multidrug Efflux Inhibitors for Gram-Negative Bacteria
    Marshall, Robert L.
    Lloyd, Georgina S.
    Lawler, Amelia J.
    Element, Sarah J.
    Kaur, Jaswant
    Ciusa, Maria Laura
    Ricci, Vito
    Tschumi, Andreas
    Kuhne, Holger
    Alderwick, Luke J.
    Piddock, Laura J., V
    MBIO, 2020, 11 (04): : 1 - 19
  • [29] Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria
    Pages, Jean-Marie
    Amaral, Leonard
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2009, 1794 (05): : 826 - 833
  • [30] Bile compounds are effective inducer of efflux pump-mediated antimicrobial resistance among Gram-negative bacteria
    Akbari, Hanieh
    Azargun, Robab
    Yekani, Mina
    Ahmadi, Somayeh
    Ghanbari, Hadi
    Memar, Mohammad Yousef
    Pirzadeh, Tahereh
    BIOLOGIA, 2025, : 1443 - 1456