Oxidative decarbonylative coupling of aliphatic aldehydes with methacryloyl benzamides to generate isoquinoline-1,3(2H,4H)-diones

被引：33

作者：

Pan, Changduo ^{[1
]}

Chen, Chaoyue ^{[1
]}

Yu, Jin-Tao ^{[2
]}

机构：

[1] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China

[2] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ARYL ISONITRILES; CYCLIZATION; ALKYLATION; ALKENES; ACCESS; ADDITION/CYCLIZATION; AMINOPEPTIDASE; IDENTIFICATION; ALKYLARYLATION; AROMATIZATION;

D O I：

10.1039/c6ob02533a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl-substituted isoquinoline-1,3(2H,4H)-diones were prepared by decarbonylative coupling of N-alkyl-N-methacryloylbenzamides and aliphatic aldehydes under metal-free conditions. The reaction undergoes subsequent decarbonylation, radical addition and cyclization processes with aliphatic aldehydes as the cheap and abundant alkyl radical source. This procedure offers a complementary approach to the convenient generation of alkyl-substituted isoquinoline-1,3(2H,4H)-diones.

引用

页码：1096 / 1099

页数：4

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