The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice

被引：36

作者：

Fu, Xiang ^{[1
,2
]}

Zhong, Zhiwen ^{[1
]}

Hu, Feng ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

Li, Chunxia ^{[1
]}

Yan, Peng ^{[1
]}

Feng, Lixue ^{[3
]}

Shen, Jinglian ^{[3
]}

Huang, Bei ^{[1
,2
]}

机构：

[1] Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China

[2] Anhui Univ, Ctr Syem Cell & Translat Med, Hefei 230601, Anhui, Peoples R China

[3] Bozhou Decoct Pieces Factory Tribute Med, Bozhou 236800, Peoples R China

来源：

FOOD & FUNCTION | 2018年 / 9卷 / 06期

关键词：

ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; DEFICIENT RATS; C-PHYCOCYANIN; APOPTOSIS; DISEASE; ACCUMULATION; EXPOSURE; ASSAY; FISH;

D O I：

10.1039/c8fo00477c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the protective effect and mechanism of selenium-enriched Spirulina platensis (S. platensis) on chronic alcohol-induced liver injury. Selenium incubation raises the nutrition quality of S. platensis by absorption enhancement of functional elements. Our results demonstrated that the effective dose of selenium-enriched S. platensis on HL7702 cells treated with alcohol was 200 g ml(-1), containing 20% selenium. Selenium-enriched S. platensis could raise the cell survival rate by decreasing the expression of p53, Caspase3, LC3, and Caspase1 and by increasing the expression of p70s6k. In vivo experiments, where mice were pretreated with selenium-enriched S. platensis, exhibited obvious inhibition of the liver function index and this pretreatment enhanced the activity of GSH-Px and SOD in alcohol induced mice. In summary, our results indicate that the protective mechanism of selenium-enriched S. platensis on chronic alcoholic liver injury is associated with the activity enhancement of antioxidant enzymes and immunity, the inhibition of DNA damage and apoptosis, accompanied with autophagy and pyroptosis.

引用

页码：3155 / 3165

页数：11

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