Basal cell carcinoma: An updated review of pathogenesis and treatment options

被引：16

作者：

Hernandez, Loren E. ^{[1
]}

Mohsin, Noreen ^{[1
]}

Levin, Nicole ^{[2
]}

Dreyfuss, Isabella ^{[3
]}

Frech, Fabio ^{[1
]}

Nouri, Keyvan ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA

[2] Florida Atlantic Univ, Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA

[3] Nova Southeastern Univ, Dr Kiran C Patel Coll Osteopath Med, Ft Lauderdale, FL 33314 USA

来源：

DERMATOLOGIC THERAPY | 2022年 / 35卷 / 06期

关键词：

basal cell; gorlin; hedgehog; immunotherapy; targeted therapy; NONMELANOMA SKIN-CANCER; IMIQUIMOD 5-PERCENT CREAM; ACID-PHOTODYNAMIC THERAPY; SURGICAL EXCISION; RECURRENCE RATES; OPEN-LABEL; TOPICAL IMIQUIMOD; SUN EXPOSURE; FOLLOW-UP; PHASE-II;

D O I：

10.1111/dth.15501

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Basal cell carcinoma (BCC) remains the most common malignancy worldwide. BCC pathogenesis is a result of the interplay between one's environment, genetics, and phenotypic factors. BCC has a low mortality but given its increasing incidence and potential to cause local destruction thus resulting in significant morbidity, it is vital for dermatologists to remain up to date with recent updates in this malignancy's pathogenesis and treatment. This article provides a comprehensive review of the pathogenesis of BCC as well as the current treatments available and clinical trials underway. We also touch upon the updated National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology in respect to BCC's recommended treatment modalities.

引用

页数：8

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