Precystectomy nomogram for prediction of advanced bladder cancer stage

Objective: To evaluate precystectomy prediction of pT and pN stages at Accepted June 7, 2006 cystectomy. Methods: Multivariate logistic regression analyses modelled variables of print on June 23, 2006 726 evaluable patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. The first set of models predicted pT(3-4) stage Keywords: at cystectomy, and the second set predicted pN(1-3) stages at cystectomy. Bladder cancer Transurethral resection (TUR) predictors consisted of 2002 T stage, 1973 Cystectomy WHO tumour grade, presence of carcinoma in situ, age, gender, and delivery of neo-adjuvant chemotherapy. The area under the ROC curve Prediction quantified nomogram accuracy. Two hundred bootstrap resamples were Stage used to reduce overfit bias. Results: At TUR, 11% of patients were staged as pT3-4 versus 42% at cystectomy. Lymph node metastases were found in 24% of patients at cystectomy (pN1-3). The multivariate pT(3-4) nomogram was 75.7% accu rate versus 71.4% for TUR T stage. The multivariate pN(1-3) nomogram was 63.1% accurate versus 61.0% for TUR T stage. Conclusion: Multivariate nomograms are not perfect, but they do predict europeanurology to read and more accurately than TUR T stage alone. answer questions on-line. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.