Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity

被引：43
作者：
Li, Yong-Li [1 ]
Yang, Xian-Wen [1 ,2 ]
Li, Su-Mei [2 ]
Shen, Yun-Heng [1 ]
Zeng, Hua-Wu [1 ]
Liu, Xiao-Hua [1 ]
Tang, Jian [1 ]
Zhang, Wei-Dong [1 ,3 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期
关键词：
REARRANGED LANOSTANE TRITERPENOIDS; ABSOLUTE STEREOCHEMISTRY; STEM BARK; EPICYCLOGRANDISOLIDE; CYCLOGRANDISOLIDE; SACHALINENSIS; DITERPENES; LACTONES;
D O I：
10.1021/np800790h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new triterpenes (neoabieslactones A-F, 1-6) and 17 known compounds were isolated from the aerial parts of Abies chensiensis. The structures of the new triterpenes were proposed by 1D and 2D NMR spectroscopy. Compound 1 was confirmed structurally by X-ray crystallography. In a bioassay against LPS-induced NO production in RAW264.7 macrophages, three compounds, neoabieslactone E (5), (12R,13R)-8,12-epoxy-14-labden-13-ol (7), and manool (8), exhibited IC50 values of 9.1, 1.9, and 9.6 mu g/mL, respectively.
引用
收藏
页码：1065 / 1068
页数：4
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