Autoantibody Profiling for Cancer Detection

被引：26

作者：

Qiu, Ji ^{[1
]}

Hanash, Sam ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Mol Diagnost Program, Seattle, WA 98109 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2009年 / 29卷 / 01期

关键词：

Antibody; Tumor antigen; Cancer detection; Proteomics; Protein microarray; CELL LUNG-CANCER; HUMAN MALIGNANT-MELANOMA; PROTEOMICS-BASED IDENTIFICATION; EATON MYASTHENIC SYNDROME; HUMORAL IMMUNE-RESPONSE; TUMOR-ANTIGENS; PROTEIN MICROARRAYS; HEPATOCELLULAR-CARCINOMA; ANTI-P53; ANTIBODIES; SURFACE-ANTIGENS;

D O I：

10.1016/j.cll.2009.01.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Despite substantial progress in the understanding of the pathogenesis of cancer, the development and implementation of strategies for early cancer detection have lagged behind. Harnessing the immune response to tumor antigens is particularly useful for early detection because the immune response occurs early during tumor development and affords signal amplification with the end product, namely reactive immunoglobulins, being released into the circulation allowing easy access through the blood. This article presents recent developments in autoantibody profiling with a focus on proteomic approaches and applications to lung cancer.

引用

页码：31 / +

页数：18

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