The plasma membrane as a mechanochemical transducer

被引:124
|
作者
Le Roux, Anabel-Lise [1 ]
Quiroga, Xarxa [1 ]
Walani, Nikhil [2 ]
Arroyo, Marino [1 ,2 ]
Roca-Cusachs, Pere [1 ,3 ]
机构
[1] BIST, Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain
[2] Univ Politecn Catalunya BarcelonaTech, LaCaN, Barcelona, Spain
[3] Univ Barcelona, Dept Biomed Sci, E-08036 Barcelona, Spain
基金
欧洲研究理事会; 欧盟地平线“2020”;
关键词
plasma membrane; mechanotransduction; membrane tension; mechanosensor; SURFACE-AREA REGULATION; INDUCED LIPID TRAFFICKING; F-BAR PROTEINS; SHEAR-STRESS; CELL-SURFACE; CURVATURE GENERATION; AMPHIPATHIC HELICES; ENDOTHELIAL-CELLS; ION CHANNELS; MEDIATED INTERACTIONS;
D O I
10.1098/rstb.2018.0221
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment.
引用
收藏
页数:15
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