The influence of blood on targeted microbubbles

被引:15
作者
Owen, Joshua [1 ]
Grove, Philip [1 ]
Rademeyer, Paul [1 ]
Stride, Eleanor [1 ]
机构
[1] Univ Oxford, Inst Biomed Engn, Oxford OX3 7DQ, England
基金
英国工程与自然科学研究理事会;
关键词
drug delivery; targeting; blood; microbubbles; magnetic; avidin-biotin; CONTRAST AGENTS; P-SELECTIN; BINDING; NANOPARTICLES; ERYTHROCYTES; DYNAMICS; CELLS; MODEL; FLOW;
D O I
10.1098/rsif.2014.0622
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ability to successfully target the delivery of drugs and other therapeutic molecules has been a key goal of biomedical research for many decades. Despite highly promising in vitro results, however, successful translation of targeted drug delivery into clinical use has been extremely limited. This study investigates the significance of the characteristics of whole blood, which are rarely accounted for in vitro assays, as a possible explanation for the poor correlation between in vitro and in vivo experiments. It is shown using two separate model systems employing either biochemical or magnetic targeting that blood causes a substantial reduction in targeting efficiency relative to saline under the same flow conditions. This finding has important implications for the design of targeted drug delivery systems and the assays used in their development.
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页数:5
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