Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study

被引：6

作者：

Maria Mostaza, Jose ^{[1
]}

Suarez Fernandez, Carmen ^{[2
]}

Castilla Guerra, Luis ^{[3
]}

Maria Surinach, Josep ^{[4
]}

Jose Tamarit, Juan ^{[5
]}

Diaz Diaz, Jose Luis ^{[6
]}

Garcia Polo, Iluminada ^{[2
]}

Francia Santamaria, Esther ^{[7
]}

Fidalgo Fernandez, Maria Angeles ^{[8
]}

de la Guerra Acebal, Carla ^{[9
]}

Davila Ramos, Meliton Francisco ^{[10
]}

Rafols, Carles ^{[11
]}

机构：

[1] Hosp Carlos III, Internal Med Serv, Madrid 28029, Spain

[2] Hosp Univ La Princesa, Internal Med Serv, Madrid 28006, Spain

[3] Hosp Virgen Macarena, Internal Med Dept, Seville 41009, Spain

[4] Hosp Vall D Hebron, Serv Med Interna, Barcelona 08035, Spain

[5] Hosp Gen Valencia, Serv Med Interna, Valencia 46014, Spain

[6] Complejo Univ Hosp A Coruna, Serv Med Interna, La Coruna 15006, Spain

[7] Hosp Santa Creu & Sant Pau, Geriatr Unit, Barcelona 08041, Spain

[8] Hosp Univ Salamanca, Internal Med Serv, Salamanca 37120, Spain

[9] Hosp Mendaro, Internal Med Serv, Guipuzcoa 20850, Spain

[10] Hosp Ntra Sra La Candelaria, Internal Med Serv, Tenerife 38010, Spain

[11] Bayer Hispania SL, Dept Med, Barcelona 08037, Spain

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2018年 / 7卷 / 03期

关键词：

adherence; atrial fibrillation; direct oral anticoagulants; dosage; elderly; vitamin K antagonists; MORTALITY; RISK; EPIDEMIOLOGY; PREVENTION; GUIDELINES; MANAGEMENT; EFFICACY; FRAILTY; STROKE; SAFETY;

D O I：

10.2217/cer-2017-0034

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aim: To analyze the use of oral anticoagulants in elderly patients with atrial fibrillation in clinical practice. Patients & methods: Cross-sectional and multicenter study performed in atrial fibrillation patients >= 75 years treated with oral anticoagulants >= 3 months. Results: 837 patients (83.0 +/- 5.0 years; CHA(2)DS(2)-VASc 5.0 +/- 1.4; HAS-BLED 2.1 +/- 0.9; 70.8% vitamin K antagonists; 29.2% direct oral anticoagulants [DOACs]) were included. Poor adherence was observed in 27.9% of patients. Higher scores in the Pfeiffer's test and FRAIL scale were associated with poorer adherence. Among patients treated with DOACs, 62.3% received the lower doses. Having high CHADS(2) score and being older were associated with the use of low doses. Conclusion: 28% of patients had a poor adherence to anticoagulant treatment. 62% of patients were treated with the lower doses of DOACs.

引用

页码：223 / 232

页数：10

共 27 条

[11] Efficacy and safety of novel anticoagulants in the elderly
Karamichalakis, Nikolaos
Georgopoulos, Stamatis
Vlachos, Konstantinos
Liatakis, Ioannis
Efremidis, Michael
Sideris, Antonios
Letsas, Konstantinos P.
[J]. JOURNAL OF GERIATRIC CARDIOLOGY, 2016, 13 (08) : 718 - 723
[12] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, Paulus
Benussi, Stefano
Kotecha, Dipak
Ahlsson, Anders
Atar, Dan
Casadei, Barbara
Castella, Manuel
Diener, Hans-Christoph
Heidbuchel, Hein
Hendriks, Jeroen
Hindricks, Gerhard
Manolis, Antonis S.
Oldgren, Jonas
Popescu, Bogdan Alexandru
Schotten, Ulrich
Van Putte, Bart
Vardas, Panagiotis
[J]. EUROPEAN HEART JOURNAL, 2016, 37 (38) : 2893 - +
[13] Medication Adherence Measures: An Overview
Lam, Wai Yin
Fresco, Paula
[J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[14] Appropriateness of Prescribing Dabigatran Etexilate and Rivaroxaban in Patients With Nonvalvular Atrial Fibrillation: A Prospective Study
Larock, Anne-Sophie
Mullier, Francois
Sennesael, Anne-Laure
Douxfils, Jonathan
Devalet, Berangere
Chatelain, Christian
Dogne, Jean-Michel
Spinewine, Anne
[J]. ANNALS OF PHARMACOTHERAPY, 2014, 48 (10) : 1258 - 1268
[15] Improved outcomes with European Society of Cardiology guideline-adherent antithrombotic treatment in high-risk patients with atrial fibrillation: a report from the EORP-AF General Pilot Registry
Lip, Gregory Y. H.
Laroche, Cecile
Popescu, Mircea Iaochim
Rasmussen, Lars Hvilsted
Vitali-Serdoz, Laura
Dan, Gheorghe-Andrei
Kalarus, Zbigniew
Crijns, Harry J. G. M.
Oliveira, Mario Martins
Tavazzi, Luigi
Maggioni, Aldo P.
Boriani, Giuseppe
[J]. EUROPACE, 2015, 17 (12): : 1777 - 1786
[16] Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach The Euro Heart Survey on Atrial Fibrillation
Lip, Gregory Y. H.
Nieuwlaat, Robby
Pisters, Ron
Lane, Deirdre A.
Crijns, Harry J. G. M.
[J]. CHEST, 2010, 137 (02) : 263 - 272
[17] The State of the Art: Atrial Fibrillation Epidemiology, Prevention, and Treatment
Morin, Daniel P.
Bernard, Michael L.
Madias, Christopher
Rogers, Paul A.
Thihalolipavan, Sudarone
Estes, N. A. Mark, III
[J]. MAYO CLINIC PROCEEDINGS, 2016, 91 (12) : 1778 - 1810
[18] CONCURRENT AND PREDICTIVE-VALIDITY OF A SELF-REPORTED MEASURE OF MEDICATION ADHERENCE
MORISKY, DE
GREEN, LW
LEVINE, DM
[J]. MEDICAL CARE, 1986, 24 (01) : 67 - 74
[19] Mostaza JM, 2017, REV ESP CARDIOL, DOI [10.1016/j.medcli.2017.07.025, DOI 10.1016/J.MEDCLI.2017.07.025]
[20] The Impact of Frailty on Mortality, Length of Stay and Re-hospitalisation in Older Patients with Atrial Fibrillation
Nguyen, Tu N.
Cumming, Robert G.
Hilmer, Sarah N.
[J]. HEART LUNG AND CIRCULATION, 2016, 25 (06) : 551 - 557

← 1 2 3 →