Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study

被引：6

作者：

Maria Mostaza, Jose ^{[1
]}

Suarez Fernandez, Carmen ^{[2
]}

Castilla Guerra, Luis ^{[3
]}

Maria Surinach, Josep ^{[4
]}

Jose Tamarit, Juan ^{[5
]}

Diaz Diaz, Jose Luis ^{[6
]}

Garcia Polo, Iluminada ^{[2
]}

Francia Santamaria, Esther ^{[7
]}

Fidalgo Fernandez, Maria Angeles ^{[8
]}

de la Guerra Acebal, Carla ^{[9
]}

Davila Ramos, Meliton Francisco ^{[10
]}

Rafols, Carles ^{[11
]}

机构：

[1] Hosp Carlos III, Internal Med Serv, Madrid 28029, Spain

[2] Hosp Univ La Princesa, Internal Med Serv, Madrid 28006, Spain

[3] Hosp Virgen Macarena, Internal Med Dept, Seville 41009, Spain

[4] Hosp Vall D Hebron, Serv Med Interna, Barcelona 08035, Spain

[5] Hosp Gen Valencia, Serv Med Interna, Valencia 46014, Spain

[6] Complejo Univ Hosp A Coruna, Serv Med Interna, La Coruna 15006, Spain

[7] Hosp Santa Creu & Sant Pau, Geriatr Unit, Barcelona 08041, Spain

[8] Hosp Univ Salamanca, Internal Med Serv, Salamanca 37120, Spain

[9] Hosp Mendaro, Internal Med Serv, Guipuzcoa 20850, Spain

[10] Hosp Ntra Sra La Candelaria, Internal Med Serv, Tenerife 38010, Spain

[11] Bayer Hispania SL, Dept Med, Barcelona 08037, Spain

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2018年 / 7卷 / 03期

关键词：

adherence; atrial fibrillation; direct oral anticoagulants; dosage; elderly; vitamin K antagonists; MORTALITY; RISK; EPIDEMIOLOGY; PREVENTION; GUIDELINES; MANAGEMENT; EFFICACY; FRAILTY; STROKE; SAFETY;

D O I：

10.2217/cer-2017-0034

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aim: To analyze the use of oral anticoagulants in elderly patients with atrial fibrillation in clinical practice. Patients & methods: Cross-sectional and multicenter study performed in atrial fibrillation patients >= 75 years treated with oral anticoagulants >= 3 months. Results: 837 patients (83.0 +/- 5.0 years; CHA(2)DS(2)-VASc 5.0 +/- 1.4; HAS-BLED 2.1 +/- 0.9; 70.8% vitamin K antagonists; 29.2% direct oral anticoagulants [DOACs]) were included. Poor adherence was observed in 27.9% of patients. Higher scores in the Pfeiffer's test and FRAIL scale were associated with poorer adherence. Among patients treated with DOACs, 62.3% received the lower doses. Having high CHADS(2) score and being older were associated with the use of low doses. Conclusion: 28% of patients had a poor adherence to anticoagulant treatment. 62% of patients were treated with the lower doses of DOACs.

引用

页码：223 / 232

页数：10

共 27 条

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