Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA

被引：42
作者：
Tomiyama, M
Kimura, T
Maeda, T
Tanaka, H
Kannari, K
Baba, M
机构：
[1] Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Neurol Sci, Hirosaki, Aomori 0368216, Japan
[2] Hirosaki Univ, Sch Med, Dept Med 3, Hirosaki, Aomori 0368216, Japan
来源：
SYNAPSE | 2004年 / 52卷 / 03期
关键词：
Parkinson's disease; dyskinesia; striatum; dopamine; priming;
D O I：
10.1002/syn.20011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine whether the adenosine A(2A) receptor might play a role in L-DOPA-induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A(2A) receptor mRNA in response to intermittent treatment with L-DOPA in rats with dopaminergic denervation by 6-hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L-DOPA increased A(2A) receptor mRNA levels in the dopamine-depleted striatum of 6-OHDA-lesioned rats exhibiting behavioral sensitization to L-DOPA. These results suggest that A(2A) receptor activation is associated with the development of motor complications induced by L-DOPA treatment. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码：218 / 222
页数：5
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