The upregulation of Osteopontin mediates acquired resistance to EGFR-TKI in NSCLC through Integrin/FAK signaling

被引：0
|
作者：
Fu, Yulong [1 ]
Zhang, Yang [1 ]
Liu, Zeyi [1 ]
Huang, Jian-An [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China
来源：
EUROPEAN RESPIRATORY JOURNAL | 2020年 / 56卷
关键词：
Lung cancer; Treatments;
D O I：
10.1183/13993003.congress-2020.1762
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
1762
引用
收藏
页数：2
相关论文
共 31 条
  • [21] Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
    Zhang, Tao
    Pan, Zilu
    Gao, Jing
    Wu, Qingqing
    Bai, Gang
    Li, Yan
    Tong, Linjiang
    Feng, Fang
    Lai, Mengzhen
    Liu, Yingqiang
    Song, Peiran
    Ning, Yi
    Tang, Haotian
    Luo, Wen
    Chen, Yi
    Fang, Yan
    Zhang, Hui
    Liu, Qiupei
    Zhang, Yudi
    Wang, Hua
    Chen, Zhiwei
    Geng, Meiyu
    Ji, Hongbin
    Zhao, Guilong
    Zhou, Hu
    Ding, Jian
    Xie, Hua
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)
  • [22] Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway
    Yamazaki, Shota
    Higuchi, Youichi
    Ishibashi, Masayuki
    Hashimoto, Hiroko
    Yasunaga, Masahiro
    Matsumura, Yasuhiro
    Tsuchihara, Katsuya
    Tsuboi, Masahiro
    Goto, Koichi
    Ochiai, Atsushi
    Ishii, Genichiro
    CANCER SCIENCE, 2018, 109 (06): : 2063 - 2073
  • [23] Single-cell transcriptional profiling uncovers the association between EOMES+CD8+T cells and acquired EGFR-TKI resistance
    Wang, Guosheng
    Sun, Jiaxing
    Zhang, Jing
    Zhu, Qiping
    Lu, Jingjing
    Gao, Shaoyong
    Wang, Feilong
    Yin, Qi
    Wan, Yuan
    Li, Qiang
    DRUG RESISTANCE UPDATES, 2023, 66
  • [24] Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance
    Liu, Zhentao
    Chen, Zuhua
    Wang, Jingyuan
    Zhang, Mengqi
    Li, Zhongwu
    Wang, Shubin
    Dong, Bin
    Zhang, Cheng
    Gao, Jing
    Shen, Lin
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11
  • [25] Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling
    Wang, Wei
    Xia, Xinhang
    Chen, Kuifei
    Chen, Meng
    Meng, Yinnan
    Lv, Dongqing
    Yang, Haihua
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [26] Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
    Miklos, Walter
    Heffeter, Petra
    Pirker, Christine
    Hager, Sonja
    Kowol, Christian R.
    van Schoonhoven, Sushilla
    Stojanovic, Mirjana
    Keppler, Bernhard K.
    Berger, Walter
    ONCOTARGET, 2016, 7 (51): : 84556 - 84574
  • [27] NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer
    Dai, Jiali
    Lu, Xiyi
    Zhang, Chang
    Qu, Tianyu
    Li, Wei
    Su, Jun
    Guo, Renhua
    Yin, Dandan
    Wu, Pingping
    Han, Liang
    Zhang, Erbao
    MOLECULAR CANCER, 2025, 24 (01)
  • [28] Managing Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors Through Co-Targeting MEK/ERK Signaling
    Yu, Danlei
    Zhao, Wen
    Vallega, Karin A.
    Sun, Shi-Yong
    LUNG CANCER-TARGETS AND THERAPY, 2021, 12 : 1 - 10
  • [29] Increased TGF-α as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR-MET Interaction and Activation of MET Signaling in Colon Cancer Cells
    Troiani, Teresa
    Martinelli, Erika
    Napolitano, Stefania
    Vitagliano, Donata
    Ciuffreda, Loreta Pia
    Costantino, Sara
    Morgillo, Floriana
    Capasso, Anna
    Sforza, Vincenzo
    Nappi, Anna
    De Palma, Raffaele
    D'Aiuto, Elena
    Berrino, Liberato
    Bianco, Roberto
    Ciardiello, Fortunato
    CLINICAL CANCER RESEARCH, 2013, 19 (24) : 6751 - 6765
  • [30] Selective gene amplification to detect the T790M mutation in plasma from patients with advanced non-small cell lung cancer (NSCLC) who have developed epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance
    Nishikawa, Shingo
    Kimura, Hideharu
    Koba, Hayato
    Yoneda, Taro
    Watanabe, Satoshi
    Sakai, Tamami
    Hara, Johsuke
    Sone, Takashi
    Kasahara, Kazuo
    Nakao, Shinji
    JOURNAL OF THORACIC DISEASE, 2018, 10 (03) : 1431 - 1439
1234