Assessment of right ventricular responses to therapy in pulmonary hypertension

被引：5

作者：

Spruijt, Onno A. ^{[1
]}

Bogaard, Harm-Jan ^{[1
]}

Vonk-Noordegraaf, Anton ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pulm Dis, NL-1000 SN Amsterdam, Netherlands

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期

关键词：

CARDIAC MAGNETIC-RESONANCE; ENDOTHELIN-RECEPTOR ANTAGONIST; MYOCARDIAL PERFORMANCE INDEX; LONG-TERM TREATMENT; ARTERIAL-HYPERTENSION; 3-DIMENSIONAL ECHOCARDIOGRAPHY; VASODILATOR THERAPY; PROGNOSTIC VALUE; HEART-FAILURE; STROKE VOLUME;

D O I：

10.1016/j.drudis.2014.03.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Irrespective of its cause, pulmonary hypertension (PH) leads to an increase in pulmonary vascular resistance (PVR). Failing adaption of the right ventricle (RV) to the increased afterload is the main cause of death in PH patients and therefore monitoring RV function during treatment is essential. However, consensus on the optimal method for serial assessment of RV function is lacking and therefore the major clinical trials on PH-specific therapies have not provided clear answers with respect to the response of the RV to treatment. This short review will give an overview of the most important load-dependent and loadindependent parameters for assessing RV response to therapy in PH patients.

引用

页码：1246 / 1250

页数：5

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