Assessment of right ventricular responses to therapy in pulmonary hypertension

被引：5

作者：

Spruijt, Onno A. ^{[1
]}

Bogaard, Harm-Jan ^{[1
]}

Vonk-Noordegraaf, Anton ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pulm Dis, NL-1000 SN Amsterdam, Netherlands

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期

关键词：

CARDIAC MAGNETIC-RESONANCE; ENDOTHELIN-RECEPTOR ANTAGONIST; MYOCARDIAL PERFORMANCE INDEX; LONG-TERM TREATMENT; ARTERIAL-HYPERTENSION; 3-DIMENSIONAL ECHOCARDIOGRAPHY; VASODILATOR THERAPY; PROGNOSTIC VALUE; HEART-FAILURE; STROKE VOLUME;

D O I：

10.1016/j.drudis.2014.03.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Irrespective of its cause, pulmonary hypertension (PH) leads to an increase in pulmonary vascular resistance (PVR). Failing adaption of the right ventricle (RV) to the increased afterload is the main cause of death in PH patients and therefore monitoring RV function during treatment is essential. However, consensus on the optimal method for serial assessment of RV function is lacking and therefore the major clinical trials on PH-specific therapies have not provided clear answers with respect to the response of the RV to treatment. This short review will give an overview of the most important load-dependent and loadindependent parameters for assessing RV response to therapy in PH patients.

引用

页码：1246 / 1250

页数：5

共 52 条

[1] A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension [J].

Barst, RJ ;

Rubin, LJ ;

Long, WA ;

McGoon, MD ;

Rich, S ;

Badesch, DB ;

Groves, BM ;

Tapson, VF ;

Bourge, RC ;

Brundage, BH ;

Koerner, SK ;

Langleben, D ;

Keller, CA ;

Murali, S ;

Uretsky, BF ;

Clayton, LM ;

Jobsis, MM ;

Blackburn, SD ;

Shortino, D ;

Crow, JW .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :296-301

[2] Long-Term Outcomes With Ambrisentan Monotherapy in Pulmonary Arterial Hypertension [J].

Blalock, Shannon E. ;

Matulevicius, Susan ;

Mitchell, Laura C. ;

Reimold, Sharon ;

Warner, John ;

Peshock, Ronald ;

Torres, Fernando ;

Chin, Kelly M. .

JOURNAL OF CARDIAC FAILURE, 2010, 16 (02) :121-127

[3] Adrenergic Receptor Blockade Reverses Right Heart Remodeling and Dysfunction in Pulmonary Hypertensive Rats [J].

Bogaard, Harm J. ;

Natarajan, Ramesh ;

Mizuno, Shiro ;

Abbate, Antonio ;

Chang, Philip J. ;

Chau, Vinh Q. ;

Hoke, Nicholas N. ;

Kraskauskas, Donatas ;

Kasper, Michael ;

Salloum, Fadi N. ;

Voelkel, Norbert F. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (05) :652-660

[4] Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle [J].

Borgdorff, Marinus A. J. ;

Bartelds, Beatrijs ;

Dickinson, Michael G. ;

Boersma, Bibiche ;

Weij, Michel ;

Zandvoort, Andre ;

Sillje, Herman H. W. ;

Steendijk, Paul ;

de Vroomen, Maartje ;

Berger, Rolf M. F. .

EUROPEAN JOURNAL OF HEART FAILURE, 2012, 14 (09) :1067-1074

[5] Single-beat estimation of right ventricular end-systolic pressure-volume relationship [J].

Brimioulle, S ;

Wauthy, P ;

Ewalenko, P ;

Rondelet, B ;

Vermeulen, F ;

Kerbaul, F ;

Naeije, R .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 284 (05) :H1625-H1630

[6] Longitudinal Shortening Accounts for the Majority of Right Ventricular Contraction and Improves After Pulmonary Vasodilator Therapy in Normal Subjects and Patients With Pulmonary Arterial Hypertension [J].

Brown, Suzanne B. ;

Raina, Amresh ;

Katz, David ;

Szerlip, Molly ;

Wiegers, Susan E. ;

Forfia, Paul R. .

CHEST, 2011, 140 (01) :27-33

[7] Matching dicrotic notch and mean pulmonary artery pressures: Implications for effective arterial elastance [J].

Chemla, D ;

Hebert, JL ;

Coirault, C ;

Salmeron, S ;

Zamani, K ;

Lecarpentier, Y .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 271 (04) :H1287-H1295

[8] Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension [J].

Chin, Kelly M. ;

Kingman, Martha ;

de Lemos, James A. ;

Warner, John J. ;

Reimold, Sharon ;

Peshock, Ron ;

Torres, Fernando .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 101 (11) :1669-1672

[9] Bisoprolol Delays Progression Towards Right Heart Failure in Experimental Pulmonary Hypertension [J].

de Man, Frances S. ;

Handoko, M. Louis ;

van Ballegoij, Joris J. M. ;

Schalij, Ingrid ;

Bogaards, Sylvia J. P. ;

Postmus, Pieter E. ;

van der Velden, Jolanda ;

Westerhof, Nico ;

Paulus, Walter J. ;

Vonk-Noordegraaf, Anton .

CIRCULATION-HEART FAILURE, 2012, 5 (01) :97-U211

[10] Use of myocardial performance index in pediatric patients with idiopathic pulmonary arterial hypertension [J].

Dyer, Karrie L. ;

Pauliks, Linda B. ;

Das, Bibhuti ;

Shandas, Robin ;

Ivy, Dunbar ;

Shaffer, Elizabeth M. ;

Valdes-Cruz, Lilliam M. .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2006, 19 (01) :21-27

← 1 2 3 4 5 6 →