Testosterone in women-the clinical significance

被引:178
作者
Davis, Susan R. [1 ]
Wahlin-Jacobsen, Sarah [2 ]
机构
[1] Monash Univ, Sch Publ Hlth & Prevent Med, Womens Hlth Res Program, Melbourne, Vic 3004, Australia
[2] Psychiat Ctr Copenhagen, Sexol Clin, Dept Sexol Res, Copenhagen, Denmark
关键词
HORMONE-BINDING GLOBULIN; BONE-MINERAL DENSITY; SEX STEROID-HORMONES; TANDEM MASS-SPECTROMETRY; BREAST-CANCER INCIDENCE; POSTMENOPAUSAL WOMEN; ANDROGEN LEVELS; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; ENDOGENOUS TESTOSTERONE;
D O I
10.1016/S2213-8587(15)00284-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Testosterone is an essential hormone for women, with physiological actions mediated directly or via aromatisation to oestradiol throughout the body. Despite the crucial role of testosterone and the high circulating concentrations of this hormone relative to oestradiol in women, studies of its action and the effects of testosterone deficiency and replacement in women are scarce. The primary indication for the prescription of testosterone for women is loss of sexual desire, which causes affected women substantial concern. That no formulation has been approved for this purpose has not impeded the widespread use of testosterone by women-either off-label or as compounded therapy. Observational studies indicate that testosterone has favourable cardiovascular effects measured by surrogate outcomes; however, associations between endogenous testosterone and the risk of cardiovascular disease and total mortality, particularly in older women, are yet to be established. Adverse cardiovascular effects have not been seen in studies of transdermal testosterone therapy in women. Clinical trials suggest that exogenous testosterone enhances cognitive performance and improves musculoskeletal health in postmenopausal women. Unmet needs include the availability of approved testosterone formulations for women and studies to elucidate the contribution of testosterone to cardiovascular, cognitive, and musculoskeletal health and the risk of cancer.
引用
收藏
页码:980 / 992
页数:13
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