Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation

被引：15

作者：

Leal, Mariana Ferreira ^{[1
,2
]}

Ramos Cirilo, Priscila Daniele ^{[3
,4
]}

Furuya Mazzotti, Tatiane Katsue ^{[3
,4
]}

Calcagno, Danielle Queiroz ^{[1
,5
]}

Wisnieski, Fernanda ^{[1
]}

Demachki, Samia ^{[5
]}

Martinez, Margarita Cortes ^{[3
,4
]}

Assumpcao, Paulo Pimentel ^{[5
]}

Chammas, Roger ^{[3
,4
]}

Burbano, Rommel Rodriguez ^{[6
]}

Smith, Marilia Cardoso ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Ortopedia & Traumatol, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Fac Med, Dept Radiol, Lab Oncol Expt, Sao Paulo, Brazil

[4] Inst Canc Estado Sao Paulo, Ctr Invest Translat Oncol, Sao Paulo, Brazil

[5] Fed Univ Para, Hosp Univ Joao Barros Barreto, BR-66059 Belem, Para, Brazil

[6] Fed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66059 Belem, Para, Brazil

来源：

PLOS ONE | 2014年 / 9卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

CLINICOPATHOLOGICAL CHARACTERISTICS; NUMERICAL ABERRATIONS; YOUNG; IDENTIFICATION; CHROMOSOME-17; PROGNOSIS; CARCINOMA; BIOMARKER; DIFFUSE; PROTEIN;

D O I：

10.1371/journal.pone.0098583

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.

引用

页数：9

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Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C&gt;T Polymorphism and Copy Number Variation

Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation