Complex I and MDM2: hit me baby one more time

被引：1

作者：

Chipuk, Jerry Edward ^{[1
,2
,3
,4
,5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, 1425 Madison Ave,Box 1130, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Diabet Obes & Metab Inst, New York, NY 10029 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 04期

关键词：

Apoptosis; Complex I; MDM2; mitochondria; NDUFS1; ACTIVATION;

D O I：

10.1080/23723556.2019.1607457

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.

引用

页数：3

共 22 条

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