Complex I and MDM2: hit me baby one more time

被引：1
作者：
Chipuk, Jerry Edward [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, 1425 Madison Ave,Box 1130, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, Diabet Obes & Metab Inst, New York, NY 10029 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 04期
关键词：
Apoptosis; Complex I; MDM2; mitochondria; NDUFS1; ACTIVATION;
D O I：
10.1080/23723556.2019.1607457
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.
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页数：3
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