Effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of type 2 diabetes: a family-cluster randomised controlled trial

被引:111
|
作者
Bhopal, Raj S. [1 ]
Douglas, Anne [1 ]
Wallia, Sunita [1 ]
Forbes, John F. [1 ]
Lean, Michael E. J. [3 ]
Gill, Jason M. R. [3 ]
McKnight, John A. [4 ]
Sattar, Naveed [3 ]
Sheikh, Aziz [1 ,8 ]
Wild, Sarah H. [1 ]
Tuomilehto, Jaakko [5 ,6 ,7 ]
Sharma, Anu [1 ]
Bhopal, Ruby [1 ]
Smith, Joel B. E. [2 ]
Butcher, Isabella [1 ]
Murray, Gordon D. [1 ]
机构
[1] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland
[2] Univ Edinburgh, Edinburgh Clin Trials Unit, Edinburgh EH8 9AG, Midlothian, Scotland
[3] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[4] Western Gen Hosp, Metab Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[5] Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria
[6] Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
[7] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
[8] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Gen Internal Med & Primary Care, Boston, MA 02115 USA
基金
英国医学研究理事会; 英国经济与社会研究理事会;
关键词
PHYSICAL-ACTIVITY; FOLLOW-UP; PREVENTION; OBESITY; RELIABILITY; PREVALENCE; REDUCTION; MELLITUS; DIETARY; IMPACT;
D O I
10.1016/S2213-8587(13)70204-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The susceptibility to type 2 diabetes of people of south Asian descent is established, but there is little trial-based evidence for interventions to tackle this problem. We assessed a weight control and physical activity intervention in south Asian individuals in the UK. Methods We did this non-blinded trial in two National Health Service (NHS) regions in Scotland (UK). Between July 1, 2007, and Oct 31, 2009, we recruited men and women of Indian and Pakistani origin, aged 35 years or older, with waist circumference 90 cm or greater in men or 80 cm or greater in women, and with impaired glucose tolerance or impaired fasting glucose determined by oral glucose tolerance test. Families were randomised (using a random number generator program, with permuted blocks of random size, stratified by location [Edinburgh or Glasgow], ethnic group [Indian or Pakistani], and number of participants in the family [one vs more than one]) to intervention or control. Participants in the same family were not randomised separately. The intervention group received 15 visits from a dietitian over 3 years and the control group received four visits in the same period. The primary outcome was weight change at 3 years. Analysis was by modified intention to treat, excluding participants who died or were lost to follow-up. We used linear regression models to provide mean differences in baseline-adjusted weight at 3 years. This trial is registered, number ISRCTN25729565. Findings Of 1319 people who were screened with an oral glucose tolerance test, 196 (15%) had impaired glucose tolerance or impaired fasting glucose and 171 entered the trial. Participants were in 156 family clusters that were randomised (78 families with 85 participants were allocated to intervention; 78 families with 86 participants were allocated to control). 167 (98%) participants in 152 families completed the trial. Mean weight loss in the intervention group was 1.13 kg (SD 4.12), compared with a mean weight gain of 0.51 kg (3.65) in the control group, an adjusted mean difference of -1.64 kg (95% CI -2.83 to -0.44). Interpretation Modest, medium-term changes in weight are achievable as a component of lifestyle-change strategies, which might control or prevent adiposity-related diseases.
引用
收藏
页码:218 / 227
页数:10
相关论文
共 50 条
  • [41] Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial
    Johansen, Mette Y.
    Karstoft, Kristian
    MacDonald, Christopher S.
    Hansen, Katrine B.
    Ellingsgaard, Helga
    Hartmann, Bolette
    Albrechtsen, Nicolai J. Wewer
    Vaag, Allan A.
    Holst, Jens J.
    Pedersen, Bente K.
    Ried-Larsen, Mathias
    DIABETOLOGIA, 2020, 63 (11) : 2410 - 2422
  • [42] Nurse-led motivational interviewing to change the lifestyle of patients with type 2 diabetes (MILD-project): protocol for a cluster, randomized, controlled trial on implementing lifestyle recommendations
    Jansink, Renate
    Braspenning, Joze
    van der Weijden, Trudy
    Niessen, Louis
    Elwyn, Glyn
    Grol, Richard
    BMC HEALTH SERVICES RESEARCH, 2009, 9
  • [43] Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial
    Job G Godino
    Esther MF van Sluijs
    Theresa M Marteau
    Stephen Sutton
    Stephen J Sharp
    Simon J Griffin
    BMC Public Health, 12
  • [44] Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial
    Godino, Job G.
    van Sluijs, Esther M. F.
    Marteau, Theresa M.
    Sutton, Stephen
    Sharp, Stephen J.
    Griffin, Simon J.
    BMC PUBLIC HEALTH, 2012, 12
  • [45] Effects of telephone-delivered lifestyle support on the development of diabetes in participants at high risk of type 2 diabetes: J-DOIT1, a pragmatic cluster randomised trial
    Sakane, Naoki
    Kotani, Kazuhiko
    Takahashi, Kaoru
    Sano, Yoshiko
    Tsuzaki, Kokoro
    Okazaki, Kentaro
    Sato, Juichi
    Suzuki, Sadao
    Morita, Satoshi
    Oshima, Yoshitake
    Izumi, Kazuo
    Kato, Masayuki
    Ishizuka, Naoki
    Noda, Mitsuhiko
    Kuzuya, Hideshi
    BMJ OPEN, 2015, 5 (08):
  • [46] Effect of an individualised nutritional intervention on gestational diabetes mellitus prevention in a high-risk population screened by a prediction model: study protocol for a multicentre randomised controlled trial
    Zhang, Chenjie
    Wang, Lulu
    Sun, Wenguang
    Chen, Lei
    Zhang, Chen
    Li, Hong
    Yu, Jiale
    Fan, Jianxia
    Ruan, Huijuan
    Zheng, Tao
    Wu, Dongling
    Li, Shaojing
    Lu, Huan
    Wang, Man
    Mol, Ben W.
    Huang, Hefeng
    Wu, Yanting
    BMC PREGNANCY AND CHILDBIRTH, 2021, 21 (01)
  • [47] Effectiveness of a targeted lifestyle intervention in primary care on diet and physical activity among South Asians at risk for diabetes: 2-year results of a randomised controlled trial in the Netherlands
    Vlaar, Everlina M. A.
    Nierkens, Vera
    Nicolaou, Mary
    Middelkoop, Barend J. C.
    Busschers, Wim B.
    Stronks, Karien
    van Valkengoed, Irene G. M.
    BMJ OPEN, 2017, 7 (06):
  • [48] Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial
    Taheri, Shahrad
    Chagoury, Odette
    Zaghloul, Hadeel
    Elhadad, Sara
    Ahmed, Salma Hayder
    Omar, Omar
    Payra, Sherryl
    Ahmed, Salma
    El Khatib, Neda
    Abou Amona, Rasha
    El Nahas, Katie
    Bolton, Matthew
    Chaar, Henem
    Suleiman, Noor
    Jayyousi, Amin
    Zirie, Mahmoud
    Janahi, Ibrahim
    Elhag, Wahiba
    Alnaama, Abdulla
    Zainel, Abduljaleel
    Hassan, Dahlia
    Cable, Tim
    Charlson, Mary
    Wells, Martin
    Al-Hamaq, Abdulla
    Al-Abdulla, Samya
    Abou-Samra, Abdul Badi
    TRIALS, 2018, 19
  • [49] Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial
    Shahrad Taheri
    Odette Chagoury
    Hadeel Zaghloul
    Sara Elhadad
    Salma Hayder Ahmed
    Omar Omar
    Sherryl Payra
    Salma Ahmed
    Neda El Khatib
    Rasha Abou Amona
    Katie El Nahas
    Matthew Bolton
    Henem Chaar
    Noor Suleiman
    Amin Jayyousi
    Mahmoud Zirie
    Ibrahim Janahi
    Wahiba Elhag
    Abdulla Alnaama
    Abduljaleel Zainel
    Dahlia Hassan
    Tim Cable
    Mary Charlson
    Martin Wells
    Abdulla Al-Hamaq
    Samya Al-Abdulla
    Abdul Badi Abou-Samra
    Trials, 19
  • [50] Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway
    Jolle, Anne
    Asvold, Bjorn Olav
    Holmen, Jostein
    Carlsen, Sven Magnus
    Tuomilehto, Jaakko
    Bjorngaard, Johan Hakon
    Midthjell, Kristian
    BMJ OPEN DIABETES RESEARCH & CARE, 2018, 6 (01)