Synthesis, antiapoptotic biological activity and structure of an oxo-vanadium(IV) complex with an OOO ligand donor set

被引：38

作者：

del Río, D

Galindo, A

Tejedo, J

Bedoya, FJ

Ienco, A

Mealli, C

机构：

[1] Univ Sevilla, Dept Quim Inorgan, Seville 41071, Spain

[2] Univ Sevilla, Dept Bioquim Med & Biol Mol, E-41009 Seville, Spain

[3] CNR, Ist Studio Stereochim & Energet Composti Coor, I-50132 Florence, Italy

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2000年 / 3卷 / 01期

关键词：

vanadium complexes; oxo complexes; oxydiacetate complexes; apoptosis; crystal structures;

D O I：

10.1016/S1387-7003(99)00180-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The oxo-vanadium(IV) complex VO(oda) (H2O)(2) (I) (oda = oxydiacetate, O(CH2COO-)(2)) was obtained by reaction of aerobic aqueous solutions of VO(acac)(2) with oxydiacetic acid, O(CH2COOH)(2). The antiapoptotic biological activity of I was studied in insulin-producing cells. Chemically generated nitric oxide (NO) triggers apoptotic events, such as the appearance of oligonucleosomes in cytosol, and this response was prevented by the presence of 1 in the culture medium. The molecular structure of 1 has been determined by X-ny diffraction analysis. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：32 / 34

页数：3

共 43 条

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