Development of an Active Site Peptide Analog of α-Fetoprotein That Prevents Breast Cancer

被引：11

作者：

Jacobson, Herbert I. ^{[1
,3
]}

Andersen, Thomas T. ^{[2
]}

Bennett, James A. ^{[3
]}

机构：

[1] Albany Med Coll, Dept Obstet & Gynecol, Albany, NY 12208 USA

[2] Albany Med Coll, Ctr Cardiovasc Sci, Albany, NY 12208 USA

[3] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany, NY 12208 USA

来源：

CANCER PREVENTION RESEARCH | 2014年 / 7卷 / 06期

关键词：

ESTROGEN-SENSITIVE CELLS; MAMMARY-TUMOR CELLS; GROWTH-INHIBITION; MATERNAL SERUM; SECRETING HEPATOMA; MULTIPLE BIRTHS; PROBABLE ROLE; TWIN BIRTHS; RISK; RATS;

D O I：

10.1158/1940-6207.CAPR-13-0405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies associate elevated maternal serum levels of alpha-fetoprotein (AFP) with reduced breast cancer risk for parous women. Laboratory studies demonstrate direct anti-breast cancer activity of AFP. Here, we review the development of a small cyclic peptide that is an active site analog of AFP, referred to as AFPep, which is composed exclusively of amino acids, is orally active, has no discernable toxicity, and is effective for the treatment and prevention of breast cancer in animal models. (C)2014 AACR.

引用

页码：565 / 573

页数：9

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