A case of Parkinson's disease following autoimmune autonomic ganglionopathy

被引：0

作者：

Mitsutake, Akihiko ^{[1
]}

Matsumo, Hideyuki ^{[2
]}

Hatano, Keiko ^{[1
]}

Higuchi, Osamu ^{[3
]}

Nakane, Shunya ^{[4
]}

Hashida, Hideji ^{[1
]}

机构：

[1] Japanese Red Cross Med Ctr, Dept Neurol, Tokyo, Japan

[2] Mitsui Mem Hosp, Dept Neurol, Tokyo, Japan

[3] Nagasaki Kawatana Med Ctr, Dept Clin Res, Nagasaki, Japan

[4] Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Kumamoto, Japan

来源：

NEUROLOGY AND CLINICAL NEUROSCIENCE | 2019年 / 7卷 / 04期

关键词：

123I-MIBG myocardial scintigraphy; anti-ganglionic acetylcholine receptor antibody; autoimmune autonomic ganglionopathy; DAT SPECT; Parkinson's disease;

D O I：

10.1111/ncn3.12288

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

引用

页码：212 / 214

页数：3

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