A case of Parkinson's disease following autoimmune autonomic ganglionopathy

被引：0
|
作者：
Mitsutake, Akihiko [1 ]
Matsumo, Hideyuki [2 ]
Hatano, Keiko [1 ]
Higuchi, Osamu [3 ]
Nakane, Shunya [4 ]
Hashida, Hideji [1 ]
机构：
[1] Japanese Red Cross Med Ctr, Dept Neurol, Tokyo, Japan
[2] Mitsui Mem Hosp, Dept Neurol, Tokyo, Japan
[3] Nagasaki Kawatana Med Ctr, Dept Clin Res, Nagasaki, Japan
[4] Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Kumamoto, Japan
来源：
NEUROLOGY AND CLINICAL NEUROSCIENCE | 2019年 / 7卷 / 04期
关键词：
123I-MIBG myocardial scintigraphy; anti-ganglionic acetylcholine receptor antibody; autoimmune autonomic ganglionopathy; DAT SPECT; Parkinson's disease;
D O I：
10.1111/ncn3.12288
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.
引用
收藏
页码：212 / 214
页数：3
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