Role of lncRNAs in the cancer development and progression and their regulation by various phytochemicals

被引：63

作者：

Baskaran, Rathinasamy ^{[1
]}

Velmurugan, Bharath Kumar ^{[2
]}

机构：

[1] Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Miaoli County, Taiwan

[2] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City, Vietnam

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 102卷

关键词：

lncRNA; Phytochemicals; Cancer; ncRNA; miRNA; LONG NONCODING RNA; TUMOR-SUPPRESSOR LNCRNA; CELL LUNG-CANCER; LIVER-CANCER; HUMAN GLIOMA; EXPRESSION; CURCUMIN; ONCOGENE; PROLIFERATION; METASTASIS;

D O I：

10.1016/j.biopha.2018.03.077

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Long non coding RNAs (lncRNAs) are involved in modulating the expression of other non-coding RNAs (ncRNA), such as microRNAs, or target proteins through the epigenetic, transcriptional, or post-transcriptional regulations. Genomic mutations in cancer reside inside regions that do not code for proteins and these regions are often transcribed into long non coding RNAs (lncRNAs). Emerging evidences have revealed an intense involvement of lncRNAs in the cancer development and progression. Recently, emerging evidences have depicted that the phytochemicals interact with lncRNAs to modulate their activities. Such findings are highly important for the identification of therapeutic strategies against diseases that are particularly associated with an aberrant lncRNA signaling. This review aims at deciphering the role of lncRNAs in the cancer development and progression, and their regulation by various phytochemicals.

引用

页码：242 / 248

页数：7

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