Efficacy of plasmapheresis for the treatment of pure red blood cell aplasia after allogeneic stem cell transplantation

被引：11

作者：

Dellacasa, Chiara Maria ^{[1
]}

D'Ardia, Stefano ^{[2
]}

Allione, Bernardino ^{[2
]}

Aydin, Semra ^{[2
]}

Tassi, Valter ^{[3
]}

Francisci, Tiziana ^{[3
]}

Pecoraro, Clara ^{[4
]}

Busca, Alessandro ^{[1
]}

机构：

[1] AOU Citta Salute & Sci, SSCVD Trapianto Cellule Staminali Allogen, Turin, Italy

[2] AOU Citta Salute & Sci, SC Ematol, Turin, Italy

[3] AOU Citta Salute & Sci, SC Banca Sangue, Turin, Italy

[4] Osped San Giovanni Bosco, SC Immunopatol & Malattie Rare, Turin, Italy

来源：

TRANSFUSION | 2015年 / 55卷 / 12期

关键词：

ERYTHROPOIESIS; ANEMIA;

D O I：

10.1111/trf.13269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Pure red blood cell aplasia (PRCA) is a complication of ABO major-incompatible stem cell transplantation, likely due to the persistence of memory B lymphocytes of recipient origin, which produce hemagglutinins against ABO antigens on donor RBCs. At present no standard of care is established for this complication. CASE REPORT: We report a case of PRCA after allogeneic bone marrow transplantation, successfully treated with plasma exchange (PEX) after failing erythropoietin administration. RESULTS: The patient fully recovered from RBC aplasia. CONCLUSION: This case suggests a role for PEX in the treatment of PRCA after allogeneic stem cell transplantation.

引用

页码：2979 / 2982

页数：4

共 17 条

[11] Complications of therapeutic plasma exchange: A prospective study of 1,727 procedures [J].

Shemin, Douglas ;

Briggs, Doris ;

Greenan, Melanie .

JOURNAL OF CLINICAL APHERESIS, 2007, 22 (05) :270-276

[12] IMMUNOHEMATOLOGIC CONSEQUENCES OF MAJOR ABO-MISMATCHED BONE-MARROW TRANSPLANTATION [J].

SNIECINSKI, IJ ;

OIEN, L ;

PETZ, LD ;

BLUME, KG .

TRANSPLANTATION, 1988, 45 (03) :530-534

[13] Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins [J].

Stussi, Georg ;

Halter, Joerg ;

Bucheli, Eveline ;

Valli, Piero V. ;

Seebach, Lutz ;

Gmuer, Juerg ;

Gratwohl, Alois ;

Schanz, Urs ;

Passweg, Jakob R. ;

Seebach, Joerg D. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (02) :239-248

[14] Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion [J].

Verholen, F ;

Stalder, M ;

Helg, C ;

Chalandon, Y .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2004, 73 (06) :441-446

[15] Regeneration of erythropoiesis after related- and unrelated-donor BMT or peripheral blood HPC transplantation:: a major ABO mismatch means problems [J].

Worel, N ;

Greinix, HT ;

Schneider, B ;

Kurz, M ;

Rabitsch, W ;

Knöbl, P ;

Reiter, E ;

Derfler, K ;

Fischer, G ;

Hinterberger, W ;

Höcker, P ;

Kalhs, P .

TRANSFUSION, 2000, 40 (05) :543-550

[16] Treatment of pure red cell aplasia after major ABO-incompatible peripheral blood stem cell transplantation by induction of chronic graft-versus-host disease [J].

Yamaguchi, M ;

Sakai, K ;

Murata, R ;

Ueda, M .

BONE MARROW TRANSPLANTATION, 2002, 30 (08) :539-541

[17] Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review [J].

Yang, MH ;

Hsu, HC .

ANNALS OF HEMATOLOGY, 2001, 80 (05) :299-301

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