Sex differences in stroke: The contribution of coagulation

被引：95

作者：

Roy-O'Reilly, Meaghan ^{[1
]}

McCullough, Louise D. ^{[1
,2
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Sch Med, Farmington, CT 06001 USA

[2] Hartford Hosp, Stroke Ctr, Hartford, CT USA

来源：

EXPERIMENTAL NEUROLOGY | 2014年 / 259卷

关键词：

Cerebral ischemia; Thrombosis; Estrogen; Women; Vasculature; ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; HORMONE REPLACEMENT THERAPY; NITRIC-OXIDE SYNTHASE; CARDIOVASCULAR-DISEASE RISK; CEREBRAL BLOOD-VESSELS; C-REACTIVE PROTEIN; PERCUTANEOUS CORONARY INTERVENTION; SOLUBLE EPOXIDE HYDROLASE; ORAL-CONTRACEPTIVES RATIO;

D O I：

10.1016/j.expneurol.2014.02.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stroke is now the leading cause of adult disability in the United States. Women are disproportionately affected by stroke. Women increasingly outnumber men in the elderly population, the period of highest risk for stroke. However, there is also a growing recognition that fundamental sex differences are present that contribute to differential ischemic sensitivity. In addition, gonadal hormone exposure can impact coagulation and fibrinolysis, key factors in the initiation of thrombosis. In this review we will discuss sex differences in stroke, with a focus on platelets, vascular reactivity and coagulation. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：16 / 27

页数：12

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