Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

被引：65

作者：

Wang, Meilin ^{[1
,2
,3
]}

Takahashi, Atsushi ^{[4
]}

Liu, Fang ^{[5
]}

Ye, Dingwei ^{[6
]}

Ding, Qiang ^{[5
]}

Qin, Chao ^{[7
]}

Yin, Changjun ^{[7
]}

Zhang, Zhengdong ^{[2
]}

Matsuda, Koichi ^{[8
]}

Kubo, Michiaki ^{[9
]}

Na, Rong ^{[5
]}

Lin, Xiaoling ^{[5
]}

Jiang, Haowen ^{[5
]}

Ren, Shancheng ^{[10
]}

Sun, Jielin ^{[3
]}

Zheng, S. Lilly ^{[3
,11
]}

Le Marchand, Loic ^{[12
]}

Isaacs, William B. ^{[13
]}

Mo, Zengnan ^{[14
]}

Haiman, Christopher A. ^{[15
]}

Sun, Yinghao ^{[10
]}

Nakagawa, Hidewaki ^{[16
]}

Xu, Jianfeng ^{[5
,11
]}

机构：

[1] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Mol & Genet Toxicol, Key Lab Modern Toxicol, Minist Educ,Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China

[3] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC 27157 USA

[4] RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan

[5] Fudan Univ, Huashan Hosp, Fudan Inst Urol, Shanghai 200040, Peoples R China

[6] Fudan Univ, Dept Urol, Shanghai Canc Ctr, Shanghai Med Coll, Shanghai 200032, Peoples R China

[7] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing 210029, Jiangsu, Peoples R China

[8] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan

[9] RIKEN Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa 2300045, Japan

[10] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China

[11] NorthShore Univ HealthSyst, Program Personalized Canc Care, Evanston, IL 60201 USA

[12] Univ Hawaii, Ctr Canc, Dept Epidemiol Program, Honolulu, HI 96813 USA

[13] Johns Hopkins Univ, Sch Med, Dept Urol, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA

[14] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China

[15] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90089 USA

[16] RIKEN Ctr Integrat Med Sci, Lab Genome Sequencing Anal, Tokyo 1088639, Japan

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; RISK; POLYMORPHISMS; JAPANESE; BETA; RMST; SNPS;

D O I：

10.1038/ncomms9469

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genome-wide association studies (GWAS) have identified similar to 100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P = 3.59 x 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P = 6.05 x 10(-10); ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.

引用

页数：7

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← 1 2 3 4 5 →

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[21] Genome-wide association study identifies five new breast cancer susceptibility loci
Turnbull, Clare
Ahmed, Shahana
Morrison, Jonathan
Pernet, David
Renwick, Anthony
Maranian, Mel
Seal, Sheila
Ghoussaini, Maya
Hines, Sarah
Healey, Catherine S.
Hughes, Deborah
Warren-Perry, Margaret
Tapper, William
Eccles, Diana
Evans, D. Gareth
Hooning, Maartje
Schutte, Mieke
van den Ouweland, Ans
Houlston, Richard
Ross, Gillian
Langford, Cordelia
Pharoah, Paul D. P.
Stratton, Michael R.
Dunning, Alison M.
Rahman, Nazneen
Easton, Douglas F.
[J]. NATURE GENETICS, 2010, 42 (06) : 504 - U47
[22] Association of 17 Prostate Cancer Susceptibility Loci With Prostate Cancer Risk in Chinese Men
Zheng, Siqun Lilly
Hsing, Ann W.
Sun, Jielin
Chu, Lisa W.
Yu, Kai
Li, Ge
Gao, Zhengrong
Kim, Seong-Tae
Isaacs, William B.
Shen, Ming-Chang
Gao, Yu-Tang
Hoover, Robert N.
Xu, Jianfeng
[J]. PROSTATE, 2010, 70 (04) : 425 - 432
[23] A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer
Zhang, Bo
Chen, Men-Yun
Shen, Yu-Jun
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Li, Guoliang
Sun, Meng-Hong
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Wei, Gong-Hong
Shao, Zhi-Min
[J]. CANCER RESEARCH, 2018, 78 (11) : 3087 - 3097
[24] Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Michailidou, Kyriaki
Beesley, Jonathan
Lindstrom, Sara
Canisius, Sander
Dennis, Joe
Lush, Michael J.
Maranian, Mel J.
Bolla, Manjeet K.
Wang, Qin
Shah, Mitul
Perkins, Barbara J.
Czene, Kamila
Eriksson, Mikael
Darabi, Hatef
Brand, Judith S.
Bojesen, Stig E.
Nordestgaard, Borge G.
Flyger, Henrik
Nielsen, Sune F.
Rahman, Nazneen
Turnbull, Clare
Fletcher, Olivia
Peto, Julian
Gibson, Lorna
dos-Santos-Silva, Isabel
Chang-Claude, Jenny
Flesch-Janys, Dieter
Rudolph, Anja
Eilber, Ursula
Behrens, Sabine
Nevanlinna, Heli
Muranen, Taru A.
Aittomaki, Kristiina
Blomqvist, Carl
Khan, Sofia
Aaltonen, Kirsimari
Ahsan, Habibul
Kibriya, Muhammad G.
Whittemore, Alice S.
John, Esther M.
Malone, Kathleen E.
Gammon, Marilie D.
Santella, Regina M.
Ursin, Giske
Makalic, Enes
Schmidt, Daniel F.
Casey, Graham
Hunter, David J.
Gapstur, Susan M.
Gaudet, Mia M.
[J]. NATURE GENETICS, 2015, 47 (04) : 373 - +
[25] Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Ellinor, Patrick T.
Lunetta, Kathryn L.
Albert, Christine M.
Glazer, Nicole L.
Ritchie, Marylyn D.
Smith, Albert V.
Arking, Dan E.
Mueller-Nurasyid, Martina
Krijthe, Bouwe P.
Lubitz, Steven A.
Bis, Joshua C.
Chung, Mina K.
Doerr, Marcus
Ozaki, Kouichi
Roberts, Jason D.
Smith, J. Gustav
Pfeufer, Arne
Sinner, Moritz F.
Lohman, Kurt
Ding, Jingzhong
Smith, Nicholas L.
Smith, Jonathan D.
Rienstra, Michiel
Rice, Kenneth M.
Van Wagoner, David R.
Magnani, Jared W.
Wakili, Reza
Clauss, Sebastian
Rotter, Jerome I.
Steinbeck, Gerhard
Launer, Lenore J.
Davies, Robert W.
Borkovich, Matthew
Harris, Tamara B.
Lin, Honghuang
Voelker, Uwe
Voelzke, Henry
Milan, David J.
Hofman, Albert
Boerwinkle, Eric
Chen, Lin Y.
Soliman, Elsayed Z.
Voight, Benjamin F.
Li, Guo
Chakravarti, Aravinda
Kubo, Michiaki
Tedrow, Usha B.
Rose, Lynda M.
Ridker, Paul M.
Conen, David
[J]. NATURE GENETICS, 2012, 44 (06) : 670 - U88
[26] Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus
Kunz, Manfred
Koenig, Inke R.
Schillert, Arne
Kruppa, Jochen
Ziegler, Andreas
Grallert, Harald
Mueller-Nurasyid, Martina
Lieb, Wolfgang
Franke, Andre
Ranki, Annamari
Panelius, Jaana
Koskenmies, Sari
Hasan, Taina
Kere, Juha
Roenn, Ann-Charlotte
Simon, Jan C.
Schmidt, Enno
Wenzel, Joerg
Tueting, Thomas
Landsberg, Jennifer
Zeller, Tanja
Blankenberg, Stefan
Glaeser, Regine
Patsinakidis, Nikolaos
Kuhn, Annegret
Ibrahim, Saleh M.
[J]. EXPERIMENTAL DERMATOLOGY, 2015, 24 (07) : 510 - 515
[27] Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
Yin, Xianyong
Kim, Kwangwoo
Suetsugu, Hiroyuki
Bang, So-Young
Wen, Leilei
Koido, Masaru
Ha, Eunji
Liu, Lu
Sakamoto, Yuma
Jo, Sungsin
Leng, Rui-Xue
Otomo, Nao
Laurynenka, Viktoryia
Kwon, Young-Chang
Sheng, Yujun
Sugano, Nobuhiko
Hwang, Mi Yeong
Li, Weiran
Mukai, Masaya
Yoon, Kyungheon
Cai, Minglong
Ishigaki, Kazuyoshi
Chung, Won Tae
Huang, He
Takahashi, Daisuke
Lee, Shin-Seok
Wang, Mengwei
Karino, Kohei
Shim, Seung-Cheol
Zheng, Xiaodong
Miyamura, Tomoya
Kang, Young Mo
Ye, Dongqing
Nakamura, Junichi
Suh, Chang-Hee
Tang, Yuanjia
Motomura, Goro
Park, Yong-Beom
Ding, Huihua
Kuroda, Takeshi
Choe, Jung-Yoon
Li, Chengxu
Niiro, Hiroaki
Park, Youngho
Shen, Changbing
Miyamoto, Takeshi
Ahn, Ga-Young
Fei, Wenmin
Takeuchi, Tsutomu
Shin, Jung-Min
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 (05) : 632 - 640
[28] Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Schumacher, Fredrick R.
Al Olama, Ali Amin
Berndt, Sonja I.
Benlloch, Sara
Ahmed, Mahbubl
Saunders, Edward J.
Dadaev, Tokhir
Leongamornlert, Daniel
Anokian, Ezequiel
Cieza-Borrella, Clara
Goh, Chee
Brook, Mark N.
Sheng, Xin
Fachal, Laura
Dennis, Joe
Tyrer, Jonathan
Muir, Kenneth
Lophatananon, Artitaya
Stevens, Victoria L.
Gapstur, Susan M.
Carter, Brian D.
Tangen, Catherine M.
Goodman, Phyllis J.
Thompson, Ian M., Jr.
Batra, Jyotsna
Chambers, Suzanne
Moya, Leire
Clements, Judith
Horvath, Lisa
Tilley, Wayne
Risbridger, Gail P.
Gronberg, Henrik
Aly, Markus
Nordstrom, Tobias
Pharoah, Paul
Pashayan, Nora
Schleutker, Johanna
Tammela, Teuvo L. J.
Sipeky, Csilla
Auvinen, Anssi
Albanes, Demetrius
Weinstein, Stephanie
Wolk, Alicja
Hakansson, Niclas
West, Catharine M. L.
Dunning, Alison M.
Burnet, Neil
Mucci, Lorelei A.
Giovannucci, Edward
Andriole, Gerald L.
[J]. NATURE GENETICS, 2018, 50 (07) : 928 - +
[29] Novel Susceptibility Loci for Second Primary Tumors/Recurrence in Head and Neck Cancer Patients: Large-Scale Evaluation of Genetic Variants
Wu, Xifeng
Spitz, Margaret R.
Lee, J. Jack
Lippman, Scott M.
Ye, Yuanqing
Yang, Hushan
Khuri, Fadlo R.
Kim, Edward
Gu, Jian
Lotan, Reuben
Hong, Waun K.
[J]. CANCER PREVENTION RESEARCH, 2009, 2 (07) : 617 - 624
[30] Two susceptibility loci identified for prostate cancer aggressiveness
Berndt, Sonja I.
Wang, Zhaoming
Yeager, Meredith
Alavanja, Michael C.
Albanes, Demetrius
Amundadottir, Laufey
Andriole, Gerald
Freeman, Laura Beane
Campa, Daniele
Cancel-Tassin, Geraldine
Canzian, Federico
Cornu, Jean-Nicolas
Cussenot, Olivier
Diver, W. Ryan
Gapstur, Susan M.
Gronberg, Henrik
Haiman, Christopher A.
Henderson, Brian
Hutchinson, Amy
Hunter, David J.
Key, Timothy J.
Kolb, Suzanne
Koutros, Stella
Kraft, Peter
Le Marchand, Loic
Lindstroem, Sara
Machiela, Mitchell J.
Ostrander, Elaine A.
Riboli, Elio
Schumacher, Fred
Siddiq, Afshan
Stanford, Janet L.
Stevens, Victoria L.
Travis, Ruth C.
Tsilidis, Konstantinos K.
Virtamo, Jarmo
Weinstein, Stephanie
Wilkund, Fredrik
Xu, Jianfeng
Zheng, S. Lilly
Yu, Kai
Wheeler, William
Zhang, Han
Consortium, African Ancestry Prostate Canc G. W. A. S.
Sampson, Joshua
Black, Amanda
Jacobs, Kevin
Hoover, Robert N.
Tucker, Margaret
Chanock, Stephen J.
[J]. NATURE COMMUNICATIONS, 2015, 6

← 1 2 3 4 5 →