Progranulin and the receptor tyrosine kinase EphA2, partners in crime?

被引：9

作者：

Chitramuthu, Babykumari ^{[1
,2
]}

Bateman, Andrew ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada

[2] McGill Univ, Ctr Hlth, Res Inst, Ctr Translat Biol,Platform Expt Therapeut & Metab, Montreal, PQ H4A 3J1, Canada

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 05期

关键词：

D O I：

10.1083/jcb.201610097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol. https://doi.org/10.1083/ jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such a receptor, providing insight into progranulin and EphA2 signaling.

引用

页码：603 / 605

页数：3

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