Progranulin and the receptor tyrosine kinase EphA2, partners in crime?

被引：9

作者：

Chitramuthu, Babykumari ^{[1
,2
]}

Bateman, Andrew ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada

[2] McGill Univ, Ctr Hlth, Res Inst, Ctr Translat Biol,Platform Expt Therapeut & Metab, Montreal, PQ H4A 3J1, Canada

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 05期

关键词：

D O I：

10.1083/jcb.201610097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol. https://doi.org/10.1083/ jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such a receptor, providing insight into progranulin and EphA2 signaling.

引用

页码：603 / 605

页数：3

共 14 条

[1] ISOLATION AND SEQUENCE OF THE GRANULIN PRECURSOR CDNA FROM HUMAN BONE-MARROW REVEALS TANDEM CYSTEINE-RICH GRANULIN DOMAINS [J].

BHANDARI, V ;

PALFREE, RGE ;

BATEMAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1715-1719

[2] Therapeutic targeting of EPH receptors and their ligands [J].

Boyd, Andrew W. ;

Bartlett, Perry F. ;

Lackmann, Martin .

NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (01) :39-62

[3] The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling [J].

Brantley-Sieders, Dana M. ;

Zhuang, Guanglei ;

Hicks, Donna ;

Bin Fang, Wei ;

Hwang, Yoonha ;

Cates, Justin M. M. ;

Coffman, Karen ;

Jackson, Dowdy ;

Bruckheirner, Elizabeth ;

Muraoka-Cook, Rebecca S. ;

Chen, Jin .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :64-78

[4] Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin [J].

Hu, Fenghua ;

Padukkavidana, Thihan ;

Vaegter, Christian B. ;

Brady, Owen A. ;

Zheng, Yanqiu ;

Mackenzie, Ian R. ;

Feldman, Howard H. ;

Nykjaer, Anders ;

Strittmatter, Stephen M. .

NEURON, 2010, 68 (04) :654-667

[5] Eph Receptor Signaling and Ephrins [J].

Lisabeth, Erika M. ;

Falivelli, Giulia ;

Pasquale, Elena B. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2013, 5 (09)

[6] Functions of ephrin/Eph interactions in the development of the nervous system:: Emphasis on the hippocampal system [J].

Martínez, A ;

Soriano, E .

BRAIN RESEARCH REVIEWS, 2005, 49 (02) :211-226

[7]

Neill T., 2016, J CELL BIOL

[8] Progranulin in neurodegenerative disease [J].

Petkau, Terri L. ;

Leavitt, Blair R. .

TRENDS IN NEUROSCIENCES, 2014, 37 (07) :388-398

[9] Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage [J].

Smith, Katherine R. ;

Damiano, John ;

Franceschetti, Silvana ;

Carpenter, Stirling ;

Canafoglia, Laura ;

Morbin, Michela ;

Rossi, Giacomina ;

Pareyson, Davide ;

Mole, Sara E. ;

Staropoli, John F. ;

Sims, Katherine B. ;

Lewis, Jada ;

Lin, Wen-Lang ;

Dickson, Dennis W. ;

Dahl, Hans-Henrik ;

Bahlo, Melanie ;

Berkovic, Samuel F. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 90 (06) :1102-1107

[10] The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice [J].

Tang, Wei ;

Lu, Yi ;

Tian, Qing-Yun ;

Zhang, Yan ;

Guo, Feng-Jin ;

Liu, Guang-Yi ;

Syed, Nabeel Muzaffar ;

Lai, Yongjie ;

Lin, Edward Alan ;

Kong, Li ;

Su, Jeffrey ;

Yin, Fangfang ;

Ding, Ai-Hao ;

Zanin-Zhorov, Alexandra ;

Dustin, Michael L. ;

Tao, Jian ;

Craft, Joseph ;

Yin, Zhinan ;

Feng, Jian Q. ;

Abramson, Steven B. ;

Yu, Xiu-Ping ;

Liu, Chuan-Ju .

SCIENCE, 2011, 332 (6028) :478-484

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