Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

被引:29
作者
Badria, Farid A. [1 ]
Fayed, Hassan A. [2 ]
Ibraheem, Amira K. [3 ]
State, Ahmed F. [2 ]
Mazyed, Eman A. [4 ]
机构
[1] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 33516, Egypt
[2] Mansoura Univ, Fac Med, Dept Dermatol, Mansoura 33516, Egypt
[3] Mansoura Dermatol & Leprosy Hosp, Mansoura 35511, Egypt
[4] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Technol, Kafrelsheikh 33516, Egypt
关键词
sodium valproate; nanospanlastics; edge activators; topical delivery; androgenic alopecia; IN-VITRO CHARACTERIZATION; EX-VIVO PERMEATION; SKIN MODELS; HAIR COUNT; OPTIMIZATION; DELIVERY; DESIGN; ACID; GEL; NIOSOMES;
D O I
10.3390/pharmaceutics12090866
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sodium valproate (SV) is an antiepileptic drug that is widely used in the treatment of different seizure disorders. The topical SV has a hair regenerative potential through activating the Wnt/beta-catenin pathway and anagen phase induction. The aim of the current investigation was to fabricate nanospanlastics of SV for improving its dermal delivery by providing prolonged drug effect and increasing its permeability for treatment of androgenic alopecia (AGA). SV-loaded nanospanlastics were formulated according to 2(3) factorial design by ethanol injection method using a non-ionic surfactant (Span 60) and edge activators (EAs), such as Tween 80 and Cremophor RH 40, to explore the influence of different independent variables on entrapment efficiency (EE%) and percentage drug released after 12 h (Q(12h)) in order to choose the optimized formula using Design-Expert software. The optimized formula (F8) appeared as spherical deformable vesicles with EE% of 90.32 +/- 2.18% and Q(12h) of 90.27 +/- 1.98%. F8 exhibited significant improvement of ex vivo permeation than free SV. The clinical study exhibited no comparable difference between F8 and marketed minoxidil lotion. However, F8 demonstrates less adverse effects than minoxidil lotion. Nanospanlastics could be a safe and effective method for improving the topical delivery of SV in the management of AGA.
引用
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页码:1 / 27
页数:29
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