Characterizing DNA methylation alterations from The Cancer Genome Atlas

被引：147

作者：

Weisenberger, Daniel J. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, USC Norris Comprehens Canc Ctr,USC Epigenome Ctr, Los Angeles, CA 90089 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 01期

关键词：

ACUTE MYELOID-LEUKEMIA; IDH2; MUTATIONS; COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; 5-METHYLCYTOSINE; PHENOTYPE; 2-HYDROXYGLUTARATE; 5-FORMYLCYTOSINE; HYPERMETHYLATION; HYPOMETHYLATION;

D O I：

10.1172/JCI69740

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.

引用

页码：17 / 23

页数：7

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