Photochemical Nickel-Catalyzed Reductive Migratory Cross-Coupling of Alkyl Bromides with Aryl Bromides

被引：99

作者：

Peng, Long ^{[1
]}

Li, Zheqi ^{[1
]}

Yin, Guoyin ^{[1
]}

机构：

[1] Wuhan Univ, IAS, Wuhan 430072, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; PHOTOREDOX CATALYSIS; DUAL-CATALYSIS; NEGISHI ARYLATIONS; ORGANIC HALIDES; ALPHA-ARYLATION; HECK REACTION; LIGHT; PALLADIUM; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.8b00413

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method to access 1,1-diarylalkanes from readily available, nonactivated alkyl bromides and aryl bromides via visible-light-driven nickel and iridium dual catalysis, wherein diisopropylamine (Pr2NH) is used as the terminal stoichiometric reductant, is reported. Both primary and secondary alkyl bromides can be successfully transformed into the migratory benzylic arylation products with good selectivity. Additionally, this method showcases tolerance toward a wide array of functional groups and the presence of bases.

引用

页码：1880 / 1883

页数：4