Inflammatory Biomarkers in Refractory Congestive Heart Failure Patients Treated with Peritoneal Dialysis

被引：14
作者：
Kunin, Margarita [1 ,2 ]
Carmon, Vered [1 ,2 ]
Arad, Michael [2 ,3 ,4 ]
Levin-Iaina, Nomy [1 ,2 ]
Freimark, Dov [2 ,3 ,4 ]
Holtzman, Eli J. [1 ,2 ]
Dinour, Dganit [1 ,2 ]
机构：
[1] Chaim Sheba Med Ctr, Nephrol & Hypertens Inst, IL-5265601 Tel Hashomer, Israel
[2] Sackler Fac Med, IL-5265601 Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Heart Failure Serv, IL-5265601 Tel Hashomer, Israel
[4] Chaim Sheba Med Ctr, Inst Heart, IL-5265601 Tel Hashomer, Israel
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
关键词：
TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ELEVATED CIRCULATING LEVELS; FACTOR-ALPHA; NATRIURETIC-PEPTIDE; CYTOKINE PRODUCTION; BETA-BLOCKERS; ULTRAFILTRATION; REMOVAL; THERAPY;
D O I：
10.1155/2015/590851
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Proinflammatory cytokines play a pathogenic role in congestive heart failure. In this study, the effect of peritoneal dialysis treatment on inflammatory cytokines levels in refractory congestive heart failure patients was investigated. During the treatment, the patients reached a well-tolerated edema-free state and demonstrated significant improvement in NYHA functional class. Brain natriuretic peptide decreased significantly after 3 months of treatment and remained stable at 6 months. C-reactive protein, a plasma marker of inflammation, decreased significantly following the treatment. Circulating inflammatory cytokines TNF-alpha and IL-6 decreased significantly after 3 months of peritoneal dialysis treatment and remained low at 6 months. The reduction in circulating inflammatory cytokines levels may be partly responsible for the efficacy of peritoneal dialysis for refractory congestive heart failure.
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页数：8
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