The search for new strategies and drugs to abate the current obesity epidemic has led to the intensification of research aimed at understanding the neuroendocrine control of appetite and energy expenditure. This intensified investigation of metabolic control has also included the study of how glial cells participate in this process. Glia, the most abundant cell type in the central nervous system, perform a wide spectrum of functions and are vital for the correct functioning of neurons and neuronal circuits. Current evidence indicates that hypothalamic glia, in particular astrocytes, tanycytes and microglia, are involved in both physiological and pathophysiological mechanisms of appetite and metabolic control, at least in part by regulating the signals reaching metabolic neuronal circuits. Glia transport nutrients, hormones and neurotransmitters; they secrete growth factors, hormones, cytokines and gliotransmitters and are a source of neuroprogenitor cells. These functions are regulated, as glia also respond to numerous hormones and nutrients, with the lack of specific hormonal signaling in hypothalamic astrocytes disrupting metabolic homeostasis. Here, we review some of the more recent advances in the role of glial cells in metabolic control, with a special emphasis on the differences between glial cell responses in males and females.
机构:
Ist Super Sanita, Lab Organ & Syst Pathophysiol, Neurophysiol Unit, I-00161 Rome, ItalyIst Super Sanita, Lab Organ & Syst Pathophysiol, Neurophysiol Unit, I-00161 Rome, Italy
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Balland, Eglantine
Dam, Julie
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Univ Paris 05, INSERM, U1016, CNRS,UMR 8104,Inst Cochin, F-75000 Paris, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Dam, Julie
Langlet, Fanny
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INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Langlet, Fanny
Caron, Emilie
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INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Caron, Emilie
Steculorum, Sophie
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Steculorum, Sophie
Messina, Andrea
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Messina, Andrea
Rasika, S.
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h-index: 0
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INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Rasika, S.
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Falluel-Morel, Anthony
Anouar, Youssef
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h-index: 0
机构:
Univ Rouen, INSERM, U982, F-76821 Mont St Aignan, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Anouar, Youssef
Dehouck, Benedicte
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Dehouck, Benedicte
Trinquet, Eric
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h-index: 0
机构:
Cisbio Bioassays, F-30200 Codolet, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Trinquet, Eric
Jockers, Ralf
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h-index: 0
机构:
Univ Paris 05, INSERM, U1016, CNRS,UMR 8104,Inst Cochin, F-75000 Paris, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Jockers, Ralf
Bouret, Sebastien G.
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Univ So Calif, Childrens Hosp Los Angeles, Saban Res Inst, Neurosci Program, Los Angeles, CA 90027 USAINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Bouret, Sebastien G.
Prevot, Vincent
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
机构:
Ist Super Sanita, Lab Organ & Syst Pathophysiol, Neurophysiol Unit, I-00161 Rome, ItalyIst Super Sanita, Lab Organ & Syst Pathophysiol, Neurophysiol Unit, I-00161 Rome, Italy
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Balland, Eglantine
Dam, Julie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, INSERM, U1016, CNRS,UMR 8104,Inst Cochin, F-75000 Paris, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Dam, Julie
Langlet, Fanny
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Langlet, Fanny
Caron, Emilie
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Caron, Emilie
Steculorum, Sophie
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Steculorum, Sophie
Messina, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Messina, Andrea
Rasika, S.
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h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Rasika, S.
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机构:
Falluel-Morel, Anthony
Anouar, Youssef
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, INSERM, U982, F-76821 Mont St Aignan, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Anouar, Youssef
Dehouck, Benedicte
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Dehouck, Benedicte
Trinquet, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Cisbio Bioassays, F-30200 Codolet, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Trinquet, Eric
Jockers, Ralf
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, INSERM, U1016, CNRS,UMR 8104,Inst Cochin, F-75000 Paris, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Jockers, Ralf
Bouret, Sebastien G.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Univ So Calif, Childrens Hosp Los Angeles, Saban Res Inst, Neurosci Program, Los Angeles, CA 90027 USAINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France
Bouret, Sebastien G.
Prevot, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, FranceINSERM, UMR837, Jean Pierre Aubert Res Ctr, UDSL,IMPRT, F-59000 Lille, France