Glial cells and energy balance

被引:51
作者
Argente-Arizon, Pilar [1 ,2 ]
Guerra-Cantera, Santiago [1 ,2 ]
Miguel Garcia-Segura, Luis [3 ]
Argente, Jesus [1 ,2 ]
Chowen, Julie A. [1 ,2 ]
机构
[1] Univ Autonoma Madrid, Hosp Infantil Univ Nino Jesus, Inst Salud Carlos III, Inst Invest La Princesa,Dept Pediat,CIBEROBN, Madrid, Spain
[2] Univ Autonoma Madrid, Hosp Infantil Univ Nino Jesus, Inst Salud Carlos III,Dept Pediat, Inst Invest La Princesa,Dept Pediat Endocrinol,CI, Madrid, Spain
[3] CSIC, Inst Cajal, Madrid, Spain
关键词
hypothalamic inflammation; gliosis; high-fat diet; sexual dimorphism; HIGH-FAT DIET; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; GLUCOSE-TRANSPORTER; ESTROGEN-RECEPTOR; LEPTIN-RECEPTOR; ARCUATE NUCLEUS; BODY-WEIGHT; HYPOTHALAMIC NEUROGENESIS; HIPPOCAMPAL NEUROGENESIS;
D O I
10.1530/JME-16-0182
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The search for new strategies and drugs to abate the current obesity epidemic has led to the intensification of research aimed at understanding the neuroendocrine control of appetite and energy expenditure. This intensified investigation of metabolic control has also included the study of how glial cells participate in this process. Glia, the most abundant cell type in the central nervous system, perform a wide spectrum of functions and are vital for the correct functioning of neurons and neuronal circuits. Current evidence indicates that hypothalamic glia, in particular astrocytes, tanycytes and microglia, are involved in both physiological and pathophysiological mechanisms of appetite and metabolic control, at least in part by regulating the signals reaching metabolic neuronal circuits. Glia transport nutrients, hormones and neurotransmitters; they secrete growth factors, hormones, cytokines and gliotransmitters and are a source of neuroprogenitor cells. These functions are regulated, as glia also respond to numerous hormones and nutrients, with the lack of specific hormonal signaling in hypothalamic astrocytes disrupting metabolic homeostasis. Here, we review some of the more recent advances in the role of glial cells in metabolic control, with a special emphasis on the differences between glial cell responses in males and females.
引用
收藏
页码:R59 / R71
页数:13
相关论文
共 143 条
  • [1] Structure and function of the blood-brain barrier
    Abbott, N. Joan
    Patabendige, Adjanie A. K.
    Dolman, Diana E. M.
    Yusof, Siti R.
    Begley, David J.
    [J]. NEUROBIOLOGY OF DISEASE, 2010, 37 (01) : 13 - 25
  • [2] Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions
    Acaz-Fonseca, Estefanfa
    Avila-Rodriguez, Marco
    Miguel Garcia-Segura, Luis
    Barreto, George E.
    [J]. PROGRESS IN NEUROBIOLOGY, 2016, 144 : 5 - 26
  • [3] Immune function of microglia
    Aloisi, F
    [J]. GLIA, 2001, 36 (02) : 165 - 179
  • [4] [Anonymous], 2014, NEW J SCI, DOI DOI 10.1155/2014/756240
  • [5] Sex differences in the physiology of eating
    Asarian, Lori
    Geary, Nori
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 305 (11) : R1215 - R1267
  • [6] Aromatase expression by reactive astroglia is neuroprotective
    Azcoitia, I
    Sierra, A
    Veiga, S
    Garcia-Segura, LM
    [J]. STEROIDS AND THE NERVOUS SYSTEM, 2003, 1007 : 298 - 305
  • [7] Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor β
    Baker, AE
    Brautigam, VM
    Watters, JJ
    [J]. ENDOCRINOLOGY, 2004, 145 (11) : 5021 - 5032
  • [8] Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
    Balland, Eglantine
    Dam, Julie
    Langlet, Fanny
    Caron, Emilie
    Steculorum, Sophie
    Messina, Andrea
    Rasika, S.
    Falluel-Morel, Anthony
    Anouar, Youssef
    Dehouck, Benedicte
    Trinquet, Eric
    Jockers, Ralf
    Bouret, Sebastien G.
    Prevot, Vincent
    [J]. CELL METABOLISM, 2014, 19 (02) : 293 - 301
  • [9] Differential effects of GH and GH-releasing peptide-6 on astrocytes
    Baquedano, Eva
    Chowen, Julie A.
    Argente, Jesus
    Frago, Laura M.
    [J]. JOURNAL OF ENDOCRINOLOGY, 2013, 218 (03) : 263 - 274
  • [10] BARR SI, 1995, AM J CLIN NUTR, V61, P39