Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Leprfa (SDT fatty) rat, a novel obese type 2 diabetic model

被引：7
|
作者：
Katsuda, Yoshiaki [1 ]
Kemmochi, Yusuke [2 ]
Maki, Mimi [1 ]
Sano, Ryuhei [1 ]
Ishii, Yukihito [1 ]
Miyajima, Katsuhiro [2 ]
Kakimoto, Kochi [2 ]
Ohta, Takeshi [1 ]
机构：
[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan
[2] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Hadano, Japan
来源：
ANIMAL SCIENCE JOURNAL | 2014年 / 85卷 / 05期
关键词：
blood pressure; salt; SDT fatty rat; BLOOD-PRESSURE; ZUCKER RATS; HYPERTENSION; MELLITUS;
D O I：
10.1111/asj.12191
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Salt plays an important role in the control of blood pressure in obesity and diabetes mellitus. In this study, we investigated physiological changes such as blood pressure and renal function in salt-loaded female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats. SDT fatty rats were given 1% NaCl in drinking water for 14 weeks, from 4 to 18 weeks of age. Significant salt-sensitive hypertension was observed in the salt-loaded SDT fatty rats. Moreover, the salt-loaded rats showed a decrease of creatinine clearance and deterioration on pathological renal findings, including glomerulosclerosis and tubular and interstitial lesions. Female SDT fatty rat is a useful model for investigating the mechanisms of high salt sensitivity in obesity and diabetes mellitus.
引用
收藏
页码：588 / 594
页数：7
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