Introduction of Ketamine as a G-Quadruplex-Binding Ligand Using Platinum Nanoparticle Modified Carbon Paste Electrode

被引：21

作者：

Bagheryan, Zahra ^{[1
]}

Raoof, Jahan-Bakhsh ^{[1
]}

Ojani, Reza ^{[1
]}

Hamidi-Asl, Ezat ^{[1
]}

机构：

[1] Mazandaran Univ, Eletroanalyt Chem Res Lab, Dept Analyt Chem, Fac Chem, Babol Sar, Iran

来源：

ELECTROANALYSIS | 2013年 / 25卷 / 12期

关键词：

G-quadruplex; Ketamine; Telomere; Anti-cancer; Platinum nanoparticle; HUMAN KRAS PROMOTER; DNA-BINDING; CIRCULAR-DICHROISM; HNRNP A1; DRUG; TELOMERASE; NORKETAMINE; SEQUENCE; AFFINITY; PAIN;

D O I：

10.1002/elan.201300418

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We designed an electrochemical platform by modifying a carbon paste electrode (CPE) with platinum nanoparticles to study the interaction between ketamine and the G-quadruplex structure of human telomeric DNA (G(4)HTD). The drug ketamine (Kt) was used as the model ligand and its ability for stabilizing the G-quadruplex structure was examined. The modified CPE (NPtCPE) was characterized by differential pulse voltammetry (DPV) and atomic force microscopy (AFM). The interaction of Kt with G(4)HTD was studied by DPV and the DPV current decreased with increasing Kt concentration. The results from UV-vis and circular dichroism (CD) spectroscopy showed a prominent intercalation mode between G(4)HTD and Kt.

引用

页码：2659 / 2667

页数：9

共 41 条

[1] Drug-selective electrode for ketamine determination in pharmaceutical preparations and electrochemical study of drug with BSA [J].

Alizadeh, N ;

Mehdipour, R .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 30 (03) :725-731

[2] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[3] Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review) [J].

Bell, RF ;

Dahl, JB ;

Moore, RA ;

Kalso, E .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2005, 49 (10) :1405-1428

[4] Switching and signaling at the telomere [J].

Blackburn, EH .

CELL, 2001, 106 (06) :661-673

[5] Gas chromatography-mass spectrometry assay for determination of ketamine in brain [J].

Blednov, YA ;

Simpson, VJ .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1999, 41 (2-3) :91-95

[6] Quadruplex DNA: sequence, topology and structure [J].

Burge, Sarah ;

Parkinson, Gary N. ;

Hazel, Pascale ;

Todd, Alan K. ;

Neidle, Stephen .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415

[7] Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study [J].

Carr, DB ;

Goudas, LC ;

Denman, WT ;

Brookoff, D ;

Staats, PS ;

Brennen, L ;

Green, G ;

Albin, R ;

Hamilton, D ;

Rogers, MC ;

Firestone, L ;

Lavin, PT ;

Mermelstein, F .

PAIN, 2004, 108 (1-2) :17-27

[8] Study of binding affinity and selectivity of perylene and coronene derivatives towards duplex and quadruplex DNA by ESI-MS [J].

Casagrande, Valentina ;

Alvino, Antonello ;

Bianco, Armandodoriano ;

Ortaggi, Giancarlo ;

Franceschin, Marco .

JOURNAL OF MASS SPECTROMETRY, 2009, 44 (04) :530-540

[9] Structural polymorphism within a regulatory element of the human KRAS promoter:: formation of G4-DNA recognized by nuclear proteins [J].

Cogoi, Susanna ;

Paramasivam, Manikandan ;

Spolaore, Barbara ;

Xodo, Luigi E. .

NUCLEIC ACIDS RESEARCH, 2008, 36 (11) :3765-3780

[10] G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription [J].

Cogoi, Susanna ;

Xodo, Luigi E. .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2536-2549

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