Distribution of 5-HT7 receptors in the human brain:: a preliminary autoradiographic study using [3H]SB-269970

被引：90
作者：
Varnäs, K
Thomas, DR
Tupala, E
Tiihonen, J
Hall, H [1 ]
机构：
[1] Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden
[2] GlaxoSmithKline Pharmaceut, Psychiat Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England
[3] Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70240 Kuopio, Finland
来源：
NEUROSCIENCE LETTERS | 2004年 / 367卷 / 03期
关键词：
5-HT7; receptor; H-3]SB-269970; human brain whole hemisphere autoradiography;
D O I：
10.1016/j.neulet.2004.06.025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The distribution of the 5-HT7 receptor was analyzed using the selective 5-HT7 receptor antagonist radioligand [H-3]SB-269970 and human brain whole hemisphere autoradiography. The results indicated that 5-HT7 receptors are most abundantly localized in the anterior thalamus and in the dentate gyrus. Other regions containing intermediate levels of 5-HT7 receptors included the hypothalamus, anterior cingulate gyrus, hippocampus, amygdala and certain brainstem nuclei. The distribution pattern obtained in this study supports the involvement of this receptor subtype in affective behavior and cognition. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：313 / 316
页数：4
相关论文
共 20 条
  • [11] Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine:: comparison to other mammalian species
    Martín-Cora, FJ
    Pazos, A
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 141 (01) : 92 - 104
  • [12] Role of 5-HT1A and 5-HT7 receptors in the facilitatory response induced by 8-OH-DPAT on learning consolidation
    Meneses, A
    Terrón, JA
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 121 (1-2) : 21 - 28
  • [13] SLEIGHT AJ, 1995, MOL PHARMACOL, V47, P99
  • [14] 5-HT7 Receptors
    Thomas, David R.
    Hagan, Jim J.
    [J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2004, 3 (01) : 81 - 90
  • [15] [3H]-SB-269970 radiolabels 5-HT7 receptors in rodent, pig and primate brain tissues
    Thomas, DR
    Atkinson, PJ
    Hastie, PG
    Roberts, JC
    Middlemiss, DN
    Price, GW
    [J]. NEUROPHARMACOLOGY, 2002, 42 (01) : 74 - 81
  • [16] Rat models of premalignant breast disease
    Thompson, HJ
    Singh, M
    [J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2000, 5 (04) : 409 - 420
  • [17] CHARACTERIZATION AND DISTRIBUTION OF PUTATIVE 5-HT(7) RECEPTORS IN GUINEA-PIG BRAIN
    TO, ZP
    BONHAUS, DW
    EGLEN, RM
    JAKEMAN, LB
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (01) : 107 - 116
  • [18] 5-HT7 receptors:: current knowledge and future prospects
    Vanhoenacker, P
    Haegeman, G
    Leysen, JE
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (02) : 70 - 77
  • [19] Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain
    Varnäs, K
    Halldin, C
    Hall, H
    [J]. HUMAN BRAIN MAPPING, 2004, 22 (03) : 246 - 260
  • [20] VOGT BA, 1997, HAND CHEM N, V13, P455
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