Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis

被引：55

作者：

Chandrasekar, PH ^{[1
]}

Cutright, JL ^{[1
]}

Manavathu, EK ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Internal Med, Div Infect Dis, Detroit, MI 48201 USA

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 10期

关键词：

amphotericin B; aspergillosis; guinea-pig model; micafungin; pulmonary aspergillosis; voriconazole;

D O I：

10.1111/j.1469-0691.2004.00958.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The efficacy of voriconazole in combination with amphotericin B or micafungin was studied in a transiently neutropenic guinea-pig model of invasive pulmonary aspergillosis. Guinea-pigs treated with the antifungal drugs, alone or in two-drug combinations, had an improved survival rate and reduced fungal burden in the lungs compared to untreated control animals. The efficacy of monotherapy and combination therapy was similar; activity was neither enhanced nor reduced with the two-drug combinations. Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted.

引用

页码：925 / 928

页数：5

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