Serum albumin is an independent prognostic factor for survival in soft tissue sarcomas

被引:0
作者
Camilo Barreto-Andrade, Juan [1 ]
Medina-Franco, Heriberto [1 ]
机构
[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Direcc Cirugia, Secc Cirugia Oncol, Mexico City 14080, DF, Mexico
来源
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION | 2009年 / 61卷 / 03期
关键词
Soft tissue sarcoma; Survival; Prognostic factors; Serum albumin; SINGLE INSTITUTION; LOCAL RECURRENCE; CANCER; EXTREMITY; CHEMOTHERAPY;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Soft tissue sarcomas are rare tumors with a wide clinical spectrum. Prognostic factors for survival have been identified, but they have been focused in the characteristics of the tumor. Patient related variables have not usually been considered in previous analysis. Methods. We analyzed a group of 61 patients with soft tissue sarcomas. Tumor related variables and patient related ones were recorded. Overall and disease free survival were calculated according to the Kaplan and Meier method. Prognostic factors for survival were determined by the log-rank method for univariate analysis and the Cox method for multivariate analysis. Results. Clinical and demographic characteristics are comparable to those of previous reports. Adverse prognostic factors for overall survival in multivariate analysis were advanced stage, high tumor grade, irresecability, and serum albumin. Size, high surgical risk (ASA III-IV) and a low performance status (Karnofsky less than 70) were predictive of overall survival only in univariate analysis. For disease free survival, only high tumor grade had statistical significance. Conclusions. Besides the usual tumor related prognostic factors, such as grade and stage, patient related factors, such as performance status and surgical risk should be considered when predicting survival. Specifically, serum albumin was an independent prognostic factor for overall survival.
引用
收藏
页码:198 / 204
页数:7
相关论文
共 21 条
  • [1] Long-term follow-up and prognostic factors in Ewing's sarcoma -: A multivariate analysis of 116 patients from a single institution
    Aparicio, J
    Munárriz, B
    Pastor, M
    Vera, FJ
    Castel, V
    Aparisi, F
    Montalar, J
    Badal, MD
    Gómez-Codina, J
    Herranz, C
    [J]. ONCOLOGY, 1998, 55 (01) : 20 - 26
  • [2] Armitage P., 1987, STAT METHODS MED RES, V2nd
  • [3] Regulation of skeletal-muscle-protein turnover in cancer-associated cachexia
    Baracos, VE
    [J]. NUTRITION, 2000, 16 (10) : 1015 - 1018
  • [4] ADJUVANT CYVADIC CHEMOTHERAPY FOR ADULT SOFT-TISSUE SARCOMA-REDUCED LOCAL RECURRENCE BUT NO IMPROVEMENT IN SURVIVAL - A STUDY OF THE EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT OF CANCER SOFT-TISSUE AND BONE SARCOMA GROUP
    BRAMWELL, V
    ROUESSE, J
    STEWARD, W
    SANTORO, A
    SCHRAFFORDTKOOPS, H
    BUESA, J
    RUKA, W
    PRIARIO, J
    WAGENER, T
    BURGERS, M
    VANUNNIK, J
    CONTESSO, G
    THOMAS, D
    VANGLABBEKE, M
    MARKHAM, D
    PINEDO, H
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (06) : 1137 - 1149
  • [5] LOCALIZED EXTREMITY SOFT-TISSUE SARCOMA - AN ANALYSIS OF FACTORS AFFECTING SURVIVAL
    COLLIN, C
    GODBOLD, J
    HAJDU, S
    BRENNAN, M
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (04) : 601 - 612
  • [6] COX DR, 1972, J R STAT SOC B, V34, P187
  • [7] Mechanisms of disease: Acute-phase proteins and other systemic responses to inflammation
    Gabay, C
    Kushner, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (06) : 448 - 454
  • [8] MANAGEMENT OF PRIMARY AND RECURRENT SOFT-TISSUE SARCOMA OF THE RETROPERITONEUM
    JAQUES, DP
    COIT, DG
    HAJDU, SI
    BRENNAN, MF
    [J]. ANNALS OF SURGERY, 1990, 212 (01) : 51 - 59
  • [9] Cancer statistics, 2004
    Jemal, A
    Tiwari, RC
    Murray, T
    Ghafoor, A
    Samuels, A
    Ward, E
    Feuer, EJ
    Thun, MJ
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2004, 54 (01) : 8 - 29
  • [10] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS
    KAPLAN, EL
    MEIER, P
    [J]. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) : 457 - 481