Effects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer -: A double blind randomised controlled trial
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作者:
Norman, Kristina
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Norman, Kristina
Stuebler, Dominik
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Stuebler, Dominik
Baier, Peter
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Baier, Peter
Schuetz, Tanja
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Schuetz, Tanja
Ocran, Kenneth
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Ocran, Kenneth
Holm, Eggert
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Holm, Eggert
Lochs, Herbert
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Lochs, Herbert
Pirlich, Matthias
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Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, GermanyUniv Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Pirlich, Matthias
[1
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机构:
[1] Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
[2] Univ Klinikum Mannheim, Med Univ Klin 2, Mannheim, Germany
Background & aim: Nutritional status frequently deteriorates during chemotherapy in cancer. This is associated with a poor outcome. Since creatine supplementation has shown promising results in various diseases, we investigated the effects of creatine on nutritional status in patients with colorectal cancer undergoing chemotherapy. Methods: Thirty patients with colorectal cancer undergoing chemotherapy were randomised to receive either creatine (n = 16) or placebo (n = 15) for 8 weeks. Body composition was determined with bioelectrical impedance analysis; muscle function by hand grip, hip flexion and knee extension strength and quality of life (QoL) was assessed by the QLQ30 questionnaire. Results: Neither muscle function, body cell mass (BCM) nor QoL improved, but phase angle, a marker of BCM and cell integrity, increased significantly in the intervention patients (5.3 +/- 0.3 degrees to 5.4 +/- 0.2 degrees, P = 0.030). Evaluating patients with different chemotherapy regimens, however, only intervention patients undergoing less aggressive chemotherapy were shown to benefit, increasing phase angle (5.11 +/- 0.22 degrees to 5.51 +/- 0.30 degrees, P=0.043) as well as BCM (27.22+/-2.85 to 29.60 +/- 3.54 kg, P = 0.043). Conclusion: Creatine failed to improve muscle mass or function and QoL in colorectal cancer patients but improved bioimpedance parameters that are predictive of poor outcome. Creatine might therefore be useful in patients with milder chemotherapy in order to maintain or increase BCM whereas patients undergoing aggressive chemotherapy however are not likely to benefit. (C) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
机构:
Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Deqing Hosp Tradit Chinese Med, Dept Internal Med, Huzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Zhou, Jiayue
Hu, Shouci
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Hu, Shouci
Zhang, Xiang
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Zhang, Xiang
Xia, Cong
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Xia, Cong
Wan, Songyan
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Wan, Songyan
Yang, Xiuyan
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Yang, Xiuyan
Yu, Yajuan
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Yu, Yajuan
Chen, Han
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
Chen, Han
Chen, Hongbo
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Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Peoples R China
机构:
Baqiyatallah Univ Med Sci, Student Res Comm, Tehran, IranBaqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran
Derogar Kasmaei, Seyedeh Roghayeh
Parastouei, Karim
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Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, IranBaqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran
Parastouei, Karim
Hosseini Ahangar, Behnam
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Baqiyatallah Univ Med Sci, Clin Sci Inst, Baqiyatallah Res Ctr Gastroenterol & Liver Dis BRC, Tehran, IranBaqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran
Hosseini Ahangar, Behnam
Saberifiroozi, Mehdi
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Univ Tehran Med Sci, Digest Dis Res Inst, Liver & Pancreatobiliary Dis Res Ctr LPDRC, Tehran, IranBaqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran
机构:
Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Wang, Xuan
Zeng, Huiling
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Zeng, Huiling
Li, Li
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Li, Li
Fang, Zhen
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Fang, Zhen
Xu, Lihua
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Xu, Lihua
Shi, Weijun
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Shi, Weijun
Li, Jianxin
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Li, Jianxin
Qian, Junqiu
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Qian, Junqiu
Tan, Xiaoqing
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Tan, Xiaoqing
Li, Jiezhen
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Changning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Li, Jiezhen
Qian, Ying
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机构:
Shanghai Jiao Tong Univ, Sch Publ, Sch Med, Shanghai, Peoples R China
Shanghai Jiao Tong Univ, Fac Clin Res Inst, Sch Med, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
Qian, Ying
Xie, Li
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Shanghai Jiao Tong Univ, Sch Publ, Sch Med, Shanghai, Peoples R China
Shanghai Jiao Tong Univ, Fac Clin Res Inst, Sch Med, Shanghai, Peoples R ChinaChangning Dist Beixinjing Community Hlth Serv Ctr, Beijing, Shanghai, Peoples R China
机构:
Inst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Feijo, Patricia M.
Rodrigues, Viviane D.
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Inst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Rodrigues, Viviane D.
Viana, Monica S.
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Univ Estado Rio de Janeiro, Nutr Inst, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Viana, Monica S.
dos Santos, Mylena P.
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Univ Estado Rio de Janeiro, Nutr Inst, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
dos Santos, Mylena P.
Abdelhay, Eliana
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Inst Nacl Canc Jose Alencar Gomes Silva, Bone Marrow Transplantat Lab, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Abdelhay, Eliana
Viola, Joao P.
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Inst Nacl Canc Jose Alencar Gomes Silva, Cell Biol Div, Res Coordinat, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Viola, Joao P.
de Pinho, Nivaldo B.
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Inst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Tech Support, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
de Pinho, Nivaldo B.
Martucci, Renata B.
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Inst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
Univ Estado Rio de Janeiro, Nutr Inst, Rio De Janeiro, BrazilInst Nacl Canc Jose Alencar Gomes Silva, Hosp Canc 1, Nutr & Dietet Serv, Rio De Janeiro, Brazil
机构:
ASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Karolinska Inst, Div Clin Microbiol, Dept Lab Med, Stockholm, Sweden
Karolinska Univ Hosp, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Helde-Frankling, Maria
Bergqvist, Jenny
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Capio St Gorans Hosp, Breast Ctr, Dept Surg, Stockholm, Sweden
Karolinska Inst, Dept Oncol Pathol, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Bergqvist, Jenny
Klasson, Caritha
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ASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Klasson, Caritha
Nordstrom, Marie
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Stockholms Sjukhem, Palliat Home Care Ward, Stockholm, Sweden
Stockholms Sjukhem, Hosp Ward, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Nordstrom, Marie
Hoijer, Jonas
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Karolinska Inst, Inst Environm Med, Unit Biostat, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Hoijer, Jonas
Bergman, Peter
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Karolinska Inst, Div Clin Microbiol, Dept Lab Med, Stockholm, Sweden
Karolinska Univ Hosp, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Bergman, Peter
Bjorkhem-Bergman, Linda
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机构:
ASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden
Karolinska Inst, Div Clin Microbiol, Dept Lab Med, Stockholm, Sweden
Karolinska Univ Hosp, Stockholm, SwedenASIH Stockholm Sodra, Palliat Home Care & Hosp Ward, Langbro Pk, Alvsjo, Sweden