Effects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer -: A double blind randomised controlled trial
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作者:
Norman, Kristina
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Norman, Kristina
Stuebler, Dominik
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Stuebler, Dominik
Baier, Peter
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Baier, Peter
Schuetz, Tanja
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Schuetz, Tanja
Ocran, Kenneth
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Ocran, Kenneth
Holm, Eggert
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Holm, Eggert
Lochs, Herbert
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机构:Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Lochs, Herbert
Pirlich, Matthias
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Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, GermanyUniv Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
Pirlich, Matthias
[1
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机构:
[1] Univ Med Berlin, Charite, Med Klin Schwerpunkt Gastroenterol Hepatol & Endo, D-10098 Berlin, Germany
[2] Univ Klinikum Mannheim, Med Univ Klin 2, Mannheim, Germany
Background & aim: Nutritional status frequently deteriorates during chemotherapy in cancer. This is associated with a poor outcome. Since creatine supplementation has shown promising results in various diseases, we investigated the effects of creatine on nutritional status in patients with colorectal cancer undergoing chemotherapy. Methods: Thirty patients with colorectal cancer undergoing chemotherapy were randomised to receive either creatine (n = 16) or placebo (n = 15) for 8 weeks. Body composition was determined with bioelectrical impedance analysis; muscle function by hand grip, hip flexion and knee extension strength and quality of life (QoL) was assessed by the QLQ30 questionnaire. Results: Neither muscle function, body cell mass (BCM) nor QoL improved, but phase angle, a marker of BCM and cell integrity, increased significantly in the intervention patients (5.3 +/- 0.3 degrees to 5.4 +/- 0.2 degrees, P = 0.030). Evaluating patients with different chemotherapy regimens, however, only intervention patients undergoing less aggressive chemotherapy were shown to benefit, increasing phase angle (5.11 +/- 0.22 degrees to 5.51 +/- 0.30 degrees, P=0.043) as well as BCM (27.22+/-2.85 to 29.60 +/- 3.54 kg, P = 0.043). Conclusion: Creatine failed to improve muscle mass or function and QoL in colorectal cancer patients but improved bioimpedance parameters that are predictive of poor outcome. Creatine might therefore be useful in patients with milder chemotherapy in order to maintain or increase BCM whereas patients undergoing aggressive chemotherapy however are not likely to benefit. (C) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
机构:
Mater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Mater Res Univ Queensland, Canc Biol & Care, South Brisbane, Qld, AustraliaMater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Hardy, Janet Rea
Skerman, Helen
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Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, AustraliaMater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Skerman, Helen
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Philip, Jennifer
Good, Phillip
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机构:
Mater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Mater Res Univ Queensland, Canc Biol & Care, South Brisbane, Qld, Australia
St Vincents Private Hosp, Dept Palliat Care, Brisbane, Qld, AustraliaMater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Good, Phillip
Currow, David C.
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机构:
Flinders Univ S Australia, Dept Palliat & Support Serv, Adelaide, SA, AustraliaMater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
Currow, David C.
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Mitchell, Geoffrey
Yates, Patsy
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Queensland Univ Technol, Sch Nursing, Brisbane, Qld, AustraliaMater Misericordiae Ltd, Dept Palliat & Support Care, Brisbane, Qld, Australia
机构:
Univ Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, CanadaUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Oliveira, Camila L. P.
Mello Antunes, Barbara de Moura
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Sao Paulo State Univ, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, BrazilUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Mello Antunes, Barbara de Moura
Gomes, Aline Corado
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Goias Fed Univ, Fac Nutr, Clin & Sports Nutr Res Lab, 227 St,Block 68, BR-74605080 Goiania, Go, BrazilUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Gomes, Aline Corado
Lira, Fabio Santos
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Sao Paulo State Univ, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, BrazilUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Lira, Fabio Santos
Pimentel, Gustavo Duarte
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Goias Fed Univ, Fac Nutr, Clin & Sports Nutr Res Lab, 227 St,Block 68, BR-74605080 Goiania, Go, BrazilUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Pimentel, Gustavo Duarte
Boule, Normand G.
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Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB T6G 2H9, CanadaUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
Boule, Normand G.
Mota, Joao Felipe
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Goias Fed Univ, Fac Nutr, Clin & Sports Nutr Res Lab, 227 St,Block 68, BR-74605080 Goiania, Go, BrazilUniv Alberta, Dept Agr Food & Nutr Sci, Human Nutr Res Unit, Edmonton, AB T6G 2E1, Canada
机构:
Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Wong, Ting Xuan
Wong, Wei Xiang
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Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Wong, Wei Xiang
Chen, Seong Ting
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Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Chen, Seong Ting
Ong, Shu Hwa
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Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Ong, Shu Hwa
Shyam, Sangeetha
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Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Shyam, Sangeetha
Ahmed, Nurzarina
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Hosp Tuanku Jaafar, Dept Gen Surg, Seremban 70300, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Ahmed, Nurzarina
Hamdan, Khairul Hazim
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Hosp Kuala Lumpur, Dept Gen Surg, Kuala Lumpur 50586, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Hamdan, Khairul Hazim
Awang, Raflis Ruzairee
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Hosp Kuala Lumpur, Dept Gen Surg, Kuala Lumpur 50586, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Awang, Raflis Ruzairee
Ibrahim, Mohd Razali
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Hosp Kuala Lumpur, Dept Gen Surg, Kuala Lumpur 50586, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Ibrahim, Mohd Razali
Palayan, Kandasami
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Int Med Univ, Sch Med, Dept Surg, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
Palayan, Kandasami
Chee, Winnie Siew Swee
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Int Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, MalaysiaInt Med Univ, Sch Hlth Sci, Div Nutr & Dietet, Kuala Lumpur 57000, Malaysia
机构:
Vrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Vrije Univ, Dept Nutr & Dietet, Internal Med, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
van der Werf, A.
Langius, J. A. E.
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Vrije Univ, Dept Nutr & Dietet, Internal Med, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
The Hague Univ Appl Sci, Dept Nutr & Dietet, Fac Hlth Nutr & Sport, POB 13336, NL-2501 EH The Hague, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Langius, J. A. E.
Beeker, A.
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机构:
Spaarne Gasthuis, Dept Med Oncol, POB 417, NL-2000 AK Haarlem, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Beeker, A.
ten Tije, A. J.
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机构:
Amphia Ziekenhuis, Dept Med Oncol, POB 90157, NL-4800 RL Breda, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
ten Tije, A. J.
Vulink, A. J.
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机构:
Reinier de Graaf Gasthuis, Dept Med Oncol, POB 5011, NL-2600 GA Delft, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Vulink, A. J.
Haringhuizen, A.
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机构:
Ziekenhuis Gelderse Vallei, Dept Med Oncol, POB 9025, NL-6710 HN Ede, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Haringhuizen, A.
Berkhof, J.
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Vrije Univ, Dept Epidemiol & Biostat, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Berkhof, J.
van der Vliet, H. J.
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Vrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
van der Vliet, H. J.
Verheul, H. M. W.
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Vrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
Verheul, H. M. W.
de van der Schueren, M. A. E.
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机构:
Vrije Univ, Dept Nutr & Dietet, Internal Med, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands
HAN Univ Appl Sci, Dept Nutr & Hlth, Fac Hlth & Social Studies, POB 6960, NL-6503 GL Nijmegen, NetherlandsVrije Univ, Dept Med Oncol, Canc Ctr Amsterdam, Amsterdam UMC, POB 7057, NL-1081 HV Amsterdam, Netherlands