Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides

被引：6
|
作者：
Maria Munoz-Molina, Jose [1 ]
Perez, Pedro J. [1 ]
机构：
[1] Univ Huelva, Lab Catalisis Homogenea, CIQSO Ctr Invest Quim Sostenible, Unidad Asociada,CSIC, Huelva 21007, Spain
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 12期
关键词：
TRANSFER RADICAL-ADDITION; ELECTRON-DEFICIENT; COUPLING REACTIONS; EFFICIENT; ALKENES; HALIDES; BENZYL; DIFLUOROALKYLATION; SECONDARY; LIGHT;
D O I：
10.1021/acs.joc.9b00898
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The complex [Cp*RuCl(PPh3)(2)] displays a high catalytic activity for the Heck-type alkenylation of alkyl bromides in the first example using this metal under thermal conditions. The coupling reaction proceeds efficiently with a variety of functionalized tertiary, secondary, and primary alkyl bromides. The presence of Hunig's base has been revealed to be crucial for this transformation. Preliminary mechanistic studies support the participation of alkyl radicals in the reaction.
引用
收藏
页码：8289 / 8296
页数：8
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