The role of the medial geniculate body of the thalamus in the pathophysiology of tinnitus and implications for treatment

被引：14

作者：

Almasabi, Faris ^{[1
,2
,3
]}

Janssen, Marcus L. F. ^{[1
,4
]}

Devos, Jana ^{[1
,5
]}

Moerel, Michelle ^{[6
,7
]}

Schwartze, Michael ^{[8
]}

Kotz, Sonja A. ^{[8
]}

Jahanshahi, Ali ^{[1
,2
]}

Temel, Yasin ^{[1
,2
]}

Smit, Jasper, V ^{[9
]}

机构：

[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Maastricht, Netherlands

[2] Maastricht Univ, Dept Neurosurg, Med Ctr, Maastricht, Netherlands

[3] King Khalid Univ, Fac Med, Physiol Dept, Abha, Saudi Arabia

[4] Maastricht Univ, Dept Neurol & Clin Neurophysiol, Med Ctr, Maastricht, Netherlands

[5] Maastricht Univ, Dept Ear Nose & Throat Head & Neck Surg, Med Ctr, Maastricht, Netherlands

[6] Maastricht Univ, Fac Psychol & Neurosci, Dept Cognit Neurosci, Maastricht, Netherlands

[7] Maastricht Univ, Fac Sci & Engn, Maastricht Ctr Syst Biol, Maastricht, Netherlands

[8] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands

[9] Zuyderland, Dept Ear Nose & Throat Head & Neck Surg, Heerlen, Netherlands

来源：

BRAIN RESEARCH | 2022年 / 1779卷

关键词：

Tinnitus; Thalamus; Medial geniculate body of thalamus; Auditory thalamus; Neuromodulation; Deep brain stimulation; DEEP BRAIN-STIMULATION; TONE-EVOKED OSCILLATIONS; AUDITORY THALAMUS; RETICULAR NUCLEUS; ELECTRICAL-STIMULATION; BEHAVIORAL EVIDENCE; COCHLEAR NUCLEUS; NETWORK ACTIVITY; HEARING-LOSS; CORTEX;

D O I：

10.1016/j.brainres.2022.147797

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tinnitus is an auditory sensation in the absence of actual external stimulation. Different clinical interventions are used in tinnitus treatment, but only few patients respond to available options. The lack of successful tinnitus treatment is partly due to the limited knowledge about the mechanisms underlying tinnitus. Recently, the auditory part of the thalamus has gained attention as a central structure in the neuropathophysiology of tinnitus. Increased thalamic spontaneous firing rate, bursting activity and oscillations, alongside an increase of GABAergic tonic inhibition have been shown in the auditory thalamus in animal models of tinnitus. In addition, clinical neuroimaging studies have shown structural and functional thalamic changes with tinnitus. This review provides a systematic overview and discussion of these observations that support a central role of the auditory thalamus in tinnitus. Based on this approach, a neuromodulative treatment option for tinnitus is proposed.

引用

页数：8

共 124 条

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