Next-generation sequencing in epigenetics

被引：1

作者：

Zeschnigk, Michael ^{[1
,2
]}

Horsthemke, Bernhard ^{[1
,2
]}

机构：

[1] Univ Duisburg Essen, Inst Humangenet, Hufelandstr 55, D-45147 Essen, Germany

[2] Univ Klinikum Essen, Hufelandstr 55, D-45147 Essen, Germany

来源：

MEDIZINISCHE GENETIK | 2019年 / 31卷 / 02期

关键词：

Epigenetics; DNA methylation; Histone modification; Nucleosomes; 3-D Chromatin folding; DNA METHYLATION; DELETION;

D O I：

10.1007/s11825-019-0245-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Molecular epigenetics refers to the chemical and physical modification of DNA and chromatin. Transcription factors determine the chromatin states of their target genes, and chromatin states affect the binding of transcription factors to DNA. Chromatin states are characterized by specific patterns of DNA methylation, histone modification, the spacing of nucleosomes and the 3-D-folding of chromatin. Since the advent of next-generation sequencing (NGS), it has become possible to analyze these patterns on a genome-wide scale and at unprecedented resolution. Such epigenetic maps are important for detecting regulatory elements, understanding normal and abnormal development and identifying epimutations.

引用

页码：205 / 211

页数：7

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