Cutaneous Melanoma - A Review of Systemic Therapies

被引：13

作者：

Lee, Karla A. ^{[1
]}

Nathan, Paul ^{[2
]}

机构：

[1] Kings Coll London, Dept Twin Res, London SE1 9RT, England

[2] Mt Vernon Canc Ctr, Northwood, Middx, England

来源：

ACTA DERMATO-VENEREOLOGICA | 2020年 / 100卷

关键词：

melanoma; systemic therapy; targeted therapy; immunotherapy; DABRAFENIB PLUS TRAMETINIB; LONG-TERM SURVIVAL; STAGE-III; METASTATIC MELANOMA; BRAF INHIBITION; DOUBLE-BLIND; OPEN-LABEL; ADJUVANT IPILIMUMAB; CHOICE CHEMOTHERAPY; COMPLETE RESECTION;

D O I：

10.2340/00015555-3496

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This decade has brought significantly improved outcomes for patients with advanced melanoma with immunotherapies and targeted treatments offering utility in a variety of settings. In 2020, we can hope for durable long-term responses, and complete remission in a subset of patients with metastatic disease. In the adjuvant setting, approximately 50% improvements in recurrence-free survival are seen both with targeted and immunotherapies. Early data from neoadjuvant immunotherapy clinical trials are very promising. However, responses to treatment are heterogeneous and not always durable; further advances are required, and several emerging strategies are of particular interest. We review the systemic treatment of melanoma, discussing the treatment of unresectable stage III-IV and recurrent disease, outlining curative treatment of cutaneous melanoma in the adjuvant setting and briefly discussing neoadjuvant systemic therapies for advanced melanoma.

引用

页码：291 / 299

页数：9

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