Lewis Acid/Bronsted Acid Controlled Pd(II)-Catalyzed Chemodivergent Functionalization of C(sp2)-H Bonds with N-(Arylthio)i(a)mides

被引：41

作者：

Chaitanya, Manthena ^{[1
]}

Anbarasan, Pazhamalai ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 11期

关键词：

C-H AMINATION; CATALYZED AMIDATION; ROOM-TEMPERATURE; ARYL SULFIDES; ACTIVATION; ARENES; TRIMETHOXYBENZENE; CHLOROAMINES; CARBAZOLES; DISULFIDES;

D O I：

10.1021/acs.orglett.8b01281

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and chemodivergent palladium-catalyzed thiolation (C-S) and imidation (C-N) of directing group assisted C-H bonds have been accomplished employing N-(arylthio)imides in combination with either Bronsted acid or Lewis acid, respectively. Notable features of the developed methodologies include excellent diversity, high functional group tolerance, wide substrate scope, and use of a single N-S reagent. Importantly, the developed hypothesis was also successfully extended to the amidation of C-H bonds. A plausible mechanistic pathway was proposed based on the preliminary mechanistic study.

引用

页码：3362 / 3366

页数：5

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